Tufts University

Benjamin P Partlow

David L Kaplan

Fiorenzo G Omenetto

Gary G Leisk

Tim Jia-Ching Lo

Stephanie L McNamara

Craig W Hanna

Rosario Friedman

The present invention provides, among other things, a elastomeric biomaterial having enzymatically cross-linked amino acid phenolic side chains to generate highly elastic hydrogels. Materials are characterized by tunable mechanical properties, gelation kinetics and swelling properties of these new protein polymers. Provided materials are support encapsulation of cells. Methods of making and using of provided particles are also disclosed.

Tunable covalently crosslinked hydrogels and methods of making the same

The present invention provides, among other things, a silk ceramic material having enzymatically cross-linked amino acid side chains to generate injectable and flexible foam ceramics. Provided are compositions and methods of producing soft, flexible ceramic foam with silk polymeric crosslinking to serve as binders. Materials have applications in osteochondral and dental replacement and repair.

Injectable, flexible hydroxyapatite-silk foams for osteochondral and dental repair

The present disclosure relates generally to compositions and methods for production of three-dimensional constructs with high mechanical strength and/or stiffness.

Silk powder compaction for production of constructs with high mechanical strength and stiffness

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Winchester, MA, United States of America

Benjamin P Partlow