Nereus Pharmaceuticals, Inc.

Progenra, Inc.

Benjamin Nicholson

Kin S Lam

Barbara Christine Potts

Ta-Hsiang Chao

Venkata Rami Reddy Macherla

Scott Sherman Mitchell

Venkat Macherla

Ram Rao Manam

Saskia Neuteboom

Cheryl L Billstrom

Joseph Weinstock

Michael A Palladino

George Kenneth Lloyd

Yoshio Hayashi

Katherine A McArthur

Suresh Kumar Kizhakkethil-George

Katherine Anne Reed

Craig Leach

William Kingsbury

Ping Cao

Scott C Mitchell

Kin Sing Lam

Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.

Anti-neoplastic compounds, compositions and methods

Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R, R', R&#x2033;, R, R, R, R, and R, Xand X, Y, Z, Z, Z, Z, and Zmay each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof

Disclosed herein are various novel oxazolidinone, imidazolidinone, and thiazolidinone analogs and methods of treating cancer and/or microbial infection using these analogs. Particular 4-oxazolidinone compounds are shown to have anti-cancer and anti-microbial activity.

Anti-cancer and anti-microbial oxazolidinones

Compounds of Formulae I-VI and derivatives thereof having anti-cancer, anti-inflammatory, and anti-microbial properties and to compositions that include one or more of compounds and their derivatives or analogs having anti-cancer, anti-inflammatory and anti-microbial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating cancer, inflammatory conditions, and microbial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

[3.2.0] Heterocyclic compounds and methods of using the same

Anti-cancer and anti-microbial 5-membered heterocyclic compounds

Compounds represented by the following structure (I), acid-addition salts and pro-drugs are disclosed: wherein the ring structure includes no substitutions, one substitution, or more than one substitution; and wherein n is equal to an integer grater than 1, preferably 2, 3, or 4; m is equal to a positive integer, preferably 1, 2 or 3, and each separate Xand X are each separately selected from a nucleophilic residue, preferably &#x2014;H, &#x2014;OH, &#x2014;O&#x2014;CO-alkyl, &#x2014;O-alkyl, &#x2014;NH, a halogen and the like; and wherein the dashed line represents a C&#x2014;C bond or a C&#x2014;H bond, and the dashed and solid line represents either a carbon-carbon single bond or a carbon-carbon double bond.

Macrocyclic lactams

Growing community of inventors

San Diego, CA, United States of America

Benjamin Nicholson