Formfactor, Inc.

Nutcracker Therapeutics, Inc.

Other

International Business Machines Corporation

Formfactor, Et Al.

Benjamin N Eldridge

Gaetan L Mathieu

Igor Y Khandros

Gary W Grube

Charles A Miller

David V Pedersen

A Nicholas Sporck

Makarand S Shinde

Ralph G Whitten

Richard A Larder

Carl V Reynolds

Eric D Hobbs

Stuart W Wenzel

Thomas H Dozier, Ii

Timothy E Cooper

Ximiao Wen

Rod Martens

Alexander H Slocum, Jr

Ken S Matsubayashi

Keith J Breinlinger

John K Gritters

Ravindra Vaman Shenoy

Stefan Graef

Onnik Yaglioglu

William D Smith

Yves Parent

Takao Saeki

Poya Lotfizadeh

Mark W Brandemuehl

Thomas H Dozier

Michael A Stadt

Chih-Chiang Tseng

Gary William Grube

Chadwick D Sofield

Barbara Vasquez

Treliant Fang

Roy John Henson

Bruce Barbara

John Ebner

Eric Hill

Nobuhiro Kawamata

Yoichi Urakawa

Alec Madsen

Thomas N Watson

Edin Sijercic

Lunyu Ma

Steven T Murphy

Richard Stephen Roy

Arthur R Zingher

Masanori Watanabe

Alexander H Slocum

Robert J Baseman

Charles Allan Brown

Michael J Armstrong

Herman Russell Wendt

James T Yeh

Douglas S Ondricek

Laura Beth Rothman

Shawn Powell

Rodney I Martens

Matthew E Chraft

Jason William Cosman

David Pritzkau

Scott Kuhnert

Yoshikazu Hatsukano

Jim Chih-Chiang Tseng

Christopher C Buckholtz

David V Pederson

Stefan Jan Juergen Zschiegner

David S Hsu

Igor Khandros

Jodi Loo

Robyn Beckwith

Adib Ahmadzadegan

Tyler Redman

Ping Wei Chen

Samir Varma

Jeffrey Coussens

Alex Madsen

Babak Sanii

Peter B Mathews

David H Hsu

Michael A Drush

Microfluidic apparatuses (e.g., systems, devices, etc.) and methods for microfluidic provide detection of polynucleotide concentration. These apparatuses may include removable, single-use or reusable microfluidic members that may include one or more channels, chambers and/or substrates for performing microfluidic maneuvers and are adapted for detection of polynucleotide concentration. For example, the microfluidic member may be a microfluidic cartridge that may be inserted, held and/or seated in a microfluidic driver apparatus that may oversee and control operations within one or more cartridges based in part on the detected concentration of polynucleotide.

Apparatuses and methods for measuring DNA/RNA production in biochips

Apparatuses and methods are described herein for processing polynucleotides in a sealed path environment. The apparatuses include optical sensors to monitor operations and to track material usage for good manufacturing practice.

Microfluidic apparatus and methods of use thereof

Filling systems and related container assemblies and methods are disclosed. In an implementation, a container assembly includes a container array, covers, a framework, and a fluidic network. The container array includes containers having distal ends and the covers are coupled to the respective distal ends of the containers. The framework is integral with: 1) the containers, 2) the covers and couples the containers together, or 3) both. The fluidic network includes fluidic channels that are defined by the framework and enable the containers to be filled in series or in parallel.

Filling systems and related container assemblies and methods

The application relates to microfluidic apparatus and methods of use thereof. Provided in one example is a microfluidic device comprising: a first fluidic input and a second fluidic input; and a fluidic intersection channel to receive fluid from the first fluidic input and the second fluidic input, wherein the fluidic intersection channel opens into a first mixing chamber on an upper region of a first side of the first mixing chamber, wherein the first mixing chamber has a length, a width, and a depth, wherein the depth is greater than about 1.5 times a depth of the fluidic intersection channel; an outlet channel on an upper region of a second side of the first mixing chamber, wherein the outlet channel has a depth that is less than the depth of the first mixing chamber, and wherein an opening of the outlet channel is offset along a width of the second side of the first mixing chamber relative to the fluidic intersection.

Mixing and microfluidic apparatuses related thereto

Microfluidic apparatuses and methods of use thereof in mixing

Improved electrically conductive guide plates for vertical probe arrays are provided by patterning a thin metal layer disposed on an insulating substrate. Holes passing through the guide plate for guiding probes can be electrically connected or isolated from each other in any pattern according to the deposition of the metal. Such structures can include several distinct ground and/or voltage planes. Furthermore, passive electrical components can be included in the guide plate, by patterning of the deposited metal and/or by integration of passive electrical components with the deposited metal traces.

Direct metalized guide plate

Crosstalk between probes in a vertical probe array is reduced by providing a grounded metal carrier disposed between the guide plates of the probe array. The metal carrier includes pockets that are laterally separated from each other by the metal carrier. Probes in different pockets are thereby electrically shielded from each other.

Shielding for vertical probe heads

Vertical probe heads having a space transformer laterally tiled into several sections are provided. This change relative to conventional approaches improves manufacturing yield. These probe heads can include metal ground planes, and in embodiments where the ground planes are provided as separate metal plates parallel to the guide plates, the metal plates can also be laterally tiled into several sections. Such tiling of metal plates improves manufacturing yield and alleviates thermal mismatch issues. Probes are not mechanically connected to the space transformer, which facilitates replacement of individual probes of an array.

Vertical probe array having a tiled membrane space transformer

Improved impedance matching is provided in vertical probe arrays having conductive guide plates by providing ground pins connecting the guide plates that do not mechanically touch the device under test or the input test apparatus. Such ground pins can be disposed in predetermined patterns around corresponding signal probes to improve an impedance match between the probes and the test apparatus and/or the device under test. Preferably all impedances are matched to 50&#x3a9; as is customary for high frequency work.

Probe head with inductance reducing structure

Electrically conductive columns of intertwined carbon nanotubes embedded in a mass of material flexible, resilient electrically insulating material can be used as electrically conductive contact probes. The columns can extend between opposing sides of the mass of material. Terminals of a wiring substrate can extend into the columns and be electrically connected to an electrical interface to a tester that controls testing of a device under test. A pair of physically interlocked structures can coupling the mass of material to the wiring substrate. The pair can include a receptacle and a protrusion.

Contactor devices with carbon nanotube probes embedded in a flexible film and processes of making such

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Hopewell Junction, NY, United States of America

Benjamin N Eldridge