Agenus Inc.

Ligand Pharmaceuticals, Inc.

Benjamin Maxime Morin

Olga Ignatovich

Nicholas Stuart Wilson

Dhan Sidhartha Chand

Dennis John Underwood

Mark Arthur Findeis

David Adam Savitsky

Cornelia Anne Mundt

Yanping Xiao

Marc A Van Dijk

Emmanuel Cyrille Pascal Briend

Spencer Campbell

Zahra Jawad

Beth Wensley

Veronica Franciszka Ilkow

Oliver Schon

Jeremy Dale Waight

Shawn Michael Jennings

Nicola Anne Ramsay

K Mark Bushell

Marc Van Dijk

Bishnu Joshi

ANTI-CD137 ANTIBODIES AND METHODS OF USE THEREOF

POLYNUCLEOTIDE ENCODING ANTI-TIGIT AND ANTI-CD96 ANTIBODIES

The instant disclosure provides multispecific molecules that specifically bind to CD96 (e.g., human CD96) and/or TIGIT (e.g., human TIGIT) and isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these multispecific molecules and antibodies, nucleic acids encoding these multispecific molecules and antibodies, expression vectors and host cells for making these multispecific molecules and antibodies, and methods of treating a subject using these multispecific molecules and antibodies.

Anti-TIGIT and anti-CD96 antibodies

The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGF&#x3b2;-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CD73 antibodies and methods of use thereof

The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-CD137 antibodies and methods of use thereof

Provided are polypeptides and compositions comprising novel HSP-binding peptides. Such polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using such polypeptides and compositions, methods of treating a disease using such polypeptides and compositions, kits comprising such polypeptides and compositions, and methods of making such compositions.

Heat shock protein-binding peptide compositions and methods of use thereof

The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.

Anti-TIGIT antibodies and methods of use thereof

Growing community of inventors

Somerville, MA, United States of America

Benjamin Maxime Morin