Novartis Ag

Other

Mereo Biopharma 1 Limited

Benjamin Martin

Francesco Venturoni

Gerhard Penn

Florian Karl Kleinbeck-Riniker

Feng Gao

Thomas Ruch

Bernhard Wietfeld

Jianguang Zhou

Can Wang

Xianglin Zhao

Zhongcheng Min

Thomas Allmendinger

Weiyong Kong

Yu Gai

Chutian Shu

Thierry Schlama

Yi Zhao

Peng Fu

Ruidong Wang

Yadong Lu

Jibin Zhao

Paolo Filipponi

Shaofeng Rong

Gottfried Sedelmeier

Werner Zaugg

Florian Andreas Rampf

Joerg Sedelmeier

Thomas Heinz

Francesca Mandrelli

Mark Meisenbach

Carmen Ruiz

Ives Mafli

Niek Johannes Ronde

Provided is a process for preparing a compound, comprising the steps of a) Reacting a compound of Formula A (Formula A) with the compound 3 (3) to provide the compound 5 (5) or a salt or solvate thereof, wherein R is a linear or branched C1-C5 alkyl. Further provided is the compound 5 or a salt or solvate thereof. (5) The use of these compounds in the synthesis of 3-[5-Amino-4-(3-Cyanobenzoyl)-Pyrazol-1-yl]-N-Cyclopropyl-4-Methylbenzamide is also provided.

Synthetic method for the preparation of a 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol compound

The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

Chemical process for preparing phenylpiperidinyl indole derivatives

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

Process and intermediates

The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

Processes and intermediates for NEP inhibitor synthesis

The present invention relates to new picolinic acid derivatives of formula (I) and their use as intermediates in the process of making pyridine derivatives, including (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide that are useful for the treatment of respiratory disorders. 

Picolinic acid derivatives and their use as intermediates

Process and intermediates for the preparation of NEP inhibitors

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Leymen, France

Benjamin Martin