University of Virginia Patent Foundation

Other

University of Massachusetts

University of Louisville Research Foundation, Inc.

Benjamin M Gaston

John F Hunt

Jonathan S Stamler

Brant E Isakson

Adam C Straub

Linda Columbus

Timothy L MacDonald

Owen W Griffith

Joan Mannick

Allan Doctor

David Gozal

Barbara Leinweber

John W Vaughan

The present invention provides compositions and methods for regulating arterial tone based on the discovery herein of novel expression and regulation of hemoglobin alpha and cytochrome B5 reductase 3 and the effects on NO and NOS.

Compositions and methods for regulating arterial tone

The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.

Airway alkalinization as therapy for airway diseases

The invention provides a method of detecting an S-nitrosothiol in a sample which includes treating the sample with a transition metal such as copper (I) and cysteine in the presence of a substance capable of blocking interactions between iron-containing compounds and NO and detecting the generated NO.

Methods for identifying and measuring S-nitrosothiol bonds in heme-containing cells and molecules

The present invention is directed to a method of treating disordered control of breathing including the treatment of apnea and hypoventilation associated with congenital or acquired brain stem abnormalities. Specifically the invention is directed to treating disordered control of breathing by administering an S-nitrosylating agent selected from the group consisting of ethyl nitrite, glutathione, nitric oxide, S-nitrosocysteine, S-nitrosoglutathione, S-nitro-N-acetyl cysteine. As shown in FIG.C the ability of endogenous SNOto increase Vin freely behaving, conscious rates using whole-body plethysmography revealed that CSNO, GSNO and CGSNO (1 nmol each) caused equivalent increases in V, whereas D-CSNO had no effect (left bar graph is the equivalent increases in V, whereas D-CSNO had no effect (left bar graph is the control whereas the right bar represents administration of the respective SNO).

Use of S-nitrosothiol signaling to treat disordered control of breathing

The present invention describes a novel, simplified method for detecting and monitoring whether the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for monitoring both normal and disease states, in the development and screening of potential therapeutic drug species.

System for detection of nitrosylated proteins

Device and method for non-invasively monitoring asthma and other respiratory diseases, as well as non-respiratory diseases. The method includes collecting condensate from a subject's breath, testing the condensate to determine its acetic acid/acetate level or concentration, and evaluating these properties to determine the presence, absence or status of a respiratory or non-respiratory disease in the subject. The method may also include, prior to the testing step, standardizing the volatile substances that may be present within the condensate in a degassing or gas standardizing step. The device includes a mouthpiece apparatus configured to receive breath from a subject, a condensation apparatus to condense the subject's breath and produce a condensate, and a collection apparatus having a collection chamber containing means for testing the condensate to determine the acetic acid and/or acetate concentration. The device may also include a system for removing or standardizing the volatile substances that may be present with the condensate. The device and method may be utilized without condensing a subject's breath and collecting the same.

Device and method for assessing asthma and other diseases

Airway alkalinization as a therapy for airway diseases

The present invention is directed to the treatment of cystic fibrosis that involves the administration of a nitrosylating agent, such as S-nitrosoglutathione or ethyl nitrite.

Therapeutic use of aerosolized S-nitrosoglutathione in cystic fibrosis

Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown.

Treating asthma by preventing and/or accomodating S-nitrosothiol breakdown

A device ( ) and method for non-invasively monitoring asthma and other respiratory diseases. The method includes collecting condensate from a subject's breath, testing the condensate to determine its acidity level or ammonium concentration, and evaluating these properties to determine the presence, absence or status of a respiratory disease in the subject. The method may also include, prior to the testing step, standardizing the volatile substances that may be present within the condensate in a degassing or gas standardizing step. The device ( ) includes a mouthpiece apparatus ( ) configured to receive breath from a subject, a condensation apparatus ( ) to condense the subject's breath and produce a condensate, and a collection apparatus ( ) having a collection chamber ( ) containing means for testing the condensate to determine its chemical properties. The device ( ) also include a system for removing or standardizing the volatile substances that may be present with the condensate.

Growing community of inventors

Charlottesville, VA, United States of America

Benjamin M Gaston