The Scripps Research Institute

Other

Benjamin List

Richard A Lerner

Carlos F Barbas, Iii

Christoph Rader

Carlos F Barbas

Guofu Zhong

Doron Shabat

The present invention provides a compound that includes an active therapeutic agent attached to a blocking moiety that is sensitive to the catalytic action of molecules having retro-aldol and retro-Michael catalytic activity, methods for making such compounds and methods of converting such compounds to active therapeutic agents using molecules having aldolase activity.

Prodrug activation using catalytic antibodies

Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.

Aldol consensations by catalytic antibodies

Aldol condensations by catalytic antibodies

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Benjamin List