Institut National De La Sante Et De La Recherche Medicale

Université Paris Diderot-Paris 7

Centre National De La Recherche Scientifique

Assistance Publique-Hopitaux De Paris

Assistance Publique - Hopitaux De Paris (Aphp)

Université De Versailles—saint-Quentin-En-Yvelines

Université Versailles Saint-Quentin-En-Yvelines

Universite Paris Cité

Benjamin Leporq

Simon Lambert

Bernard Van Beers

Bernar Van Beers

In the field of obesity related disease, identification of patients with nonalcoholic steatohepatitis (NASH) would be useful to counsel them more intensively on diet and lifestyle changes and propose new pharmacological treatments. As a consequence, the inventors worked on a method for post-processing images of a region of interest of the liver for reconstructing a map of the internal magnetic susceptibility by using a Bayesian regularization approach to inverse the internal magnetic field. Such method can be implemented on computer and provides better results than other known methods for obesity related disease. This method may be applied for predicting that a subject is at risk of suffering from such disease, diagnosing a disease, identifying a therapeutic or a biomarker and screening compounds useful as a medicine.

Method for post-processing liver MRI images to obtain a reconstructed map of the internal magnetic susceptibility

It is proposed a method for post-processing images of an region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of: &#x2014;unwrapping the phase of each image, &#x2014;extracting a complex signal over echo time for at least one pixel of the unwrapped images, and &#x2014;calculating fat characterization parameters by using a fitting technique applied on a model, the model being a function which associates to a plurality of parameters each extracted complex signal, the plurality of parameters comprising at least two fat characterization parameters, the magnitude error and the phase error generated by the use of the bipolar readout gradients, the fitting technique being a non-linear least-square fitting technique using pseudo-random initial conditions.

Method for fat characterization using MRI images acquired using a multiple gradient-echo sequence with bipolar gradients

A method for post-processing images of a region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of:

Method for post-processing magnetic resonance imaging images in a clinical context

Growing community of inventors

Clichy, France

Benjamin Leporq