Forschungszentrum Julich Gmbh

Benjamin Kaupp

Renate Gauss

Arnd Baumann

Alexander Scholten

Reinhard Seifert

Wolfgang Bönigk

The present invention relates to an isolated or purified human nucleic acid, preferably a DNA, comprising a nucleotide sequence encoding an Iion channel. The invention further relates to a vector comprising the isolated or purified nucleic acid, a host cell comprising the vector, and a composition comprising the isolated or purified nucleic acid and a carrier therefore. The invention also provides a polypeptide or protein encoded by the nucleic acid, and a method of treating a mammal for a cardiovascular disorder.

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The present invention relates to a nucleic acid, preferably a DNA, comprising at least a part of the sequence of an Iion channel. Said sequence may e.g. be derived from a human DNA, a rat DNA, a bovine DNA, aDNA or a sea urchin DNA. Furthermore, the present invention relates to an mRNA molecule which contains the corresponding sequences. The invention further relates to a polypeptide or protein encoded by the nucleic acid. Furthermore, the invention relates to the use of the inventive nucleic acid and proteins for a screening and/or diagnosing method and to the kits required therefor. Lastly, the invention relates to the use of one or more nucleic acids and proteins for the treatment and/or prophylaxis of cardiovascular disorders and disturbances of consciousness.

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Aachen, Germany

Benjamin Kaupp