California Institute of Technology

London School of Hygiene and Tropical Medicine

Northeastern University

Charité – Universitätsmedizin Berlin

Benjamin Judkewitz

Changhuei Yang

Ying Min Wang

Roarke W Horstmeyer

Guoan Zheng

Shuo Pang

Seung Ah Lee

Charles A DiMarzio

Jigang Wu

Ivo Vellekoop

Samuel Yang

Ioannis Papadopoulos

It is provided a method for identifying optical aberrations. The method comprising the steps of providing at least one first optical beam and a second optical beam; creating a combined beam by at least partially superimposing the first and the second optical beam; focusing the combined beam into or through a medium and detecting radiation excited in the medium by the combined beam due to nonlinear optical effects; detecting the radiation excited in the medium by the combined beam for each one of the phase positions, the spatial positions and/or the time positions of the first beam; and identifying aberrations using signals generated by a detection device for the plurality of the phase positions, the spatial positions and/or the time positions of the first beam relative to the second beam upon the detection of the radiation excited in the medium.

Method and arrangement for identifying optical aberrations

Methods of rapid distinction between growing cells and debris, which determine a time-lapse movie of specimen images, track features of each entity, and categorize each entity as growing cells or debris.

Methods for rapid distinction between debris and growing cells

A method and apparatus for irradiating a scattering medium with increased resolution. The method includes transmitting EM radiation from an Electromagnetic (EM) radiation source to a target inside a scattering medium, wherein the target encodes the EM radiation with a variance structure to form encoded EM radiation; measuring, in a detector, transmitted EM radiation comprising at least a portion of the encoded EM radiation transmitted through and exiting the scattering medium; decoding the transmitted EM radiation, comprising EM fields, in a computer, comprising selecting one or more of the EM fields having the variance structure; and irradiating the scattering medium with time reversed EM radiation from a spatial light modulator (SLM), the time reversed EM radiation generated from time reversing the EM fields having the variance structure, thereby forming a focus of the time reversed EM radiation in the scattering medium with the increased resolution.

Time-reversal of variance-encoded light (TROVE)

A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

Light guided pixel configured for emissions detection and comprising a guide layer with a wavelength selective filter material and a light detector layer

A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.

Deep tissue focal fluorescence imaging with digitally time-reversed ultrasound-encoded light

Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency.

Spatial frequency swept interference illumination

A device, including one or more Communication Physical Unclonable Function (CPUF) and key storage devices, the CPUF devices each including: a coherent Electromagnetic (EM) radiation source; a spatial light modulator (SLM) connected to the coherent EM radiation source; a volumetric scattering medium connected to the SLM; a detector connected to the volumetric scattering medium; and one or more processors or circuits connected to the detector and one or more processors or circuits connected to the SLM. A communication protocol is also provided.

Growing community of inventors

Los Angeles, CA, United States of America

Benjamin Judkewitz