Abbott Diabetes Care Inc.

Therasense, Inc.

Abbott Point of Care Inc.

Other

E. Heller & Company

Abbott Diabates Care Inc.

Abbott Diabetes Inc.

Benjamin J Feldman

Adam Heller

Tianmei Ouyang

Fei Mao

Joseph A Vivolo

Rajesh Krishnan

Jeffery Van Funderburk

Zenghe Liu

Ephraim Heller

Fredric C Colman

Yi Wang

Hyun Brian Cho

Geoffrey V McGarraugh

Udo Hoss

John Charles Mazza

Gary Alan Hayter

James L Say

Andrew H Naegeli

Mark S Vreeke

Benjamin Mark Rush

Shridhara Alva Karinka

Stephen Oja

Namvar Kiaie

Lam Tran

John R Galasso

Ting Chen

Suyue Qian

Brian Cho

Pawel Rowinski

Yohannes Goti

Nicolas Mano

Yueh-Lin Loo

Lei He

Louis G Pace

Glenn Brian Martin

Simon Tonks

Charlene A Haley

Jonathan D Mccanless

Tuan Anh Nguyen

Mark Kent Sloan

Phillip John Plante

Martin J Fennell

Michael R Love

Wesley Scott Harper

Jean-Pierre Cole

Mark W Eshoo

Charles T Liamos

Vivek S Rao

Robert Y Jin

Jared Watkin

Frank David Fujimoto

John V LaTour

Kevin Paul Wallis

Kuan-chou Chen

Kuan-Chou Chen

Yagya Raj Ojha

Barry S Kreutz

Jonathan McCanless

Thomas P Leary

David C Cohen

Michael S Cloud

Geoffrey V Mcgarraugh

Kenneth J Doniger

Marc Barry Taub

Phillip Yee

Gary Ashley Stafford

Daniel Milfred Bernstein

Thomas Arnold Peyser

Christopher Allen Thomas

Timothy T Goodnow

Jeffery Mario Sicurello

Theodore John Kunich

Jared L Watkin

Balasubrahmanya S Bommakanti

Kerstin Rebrin

Ashwin Kumar

Austin M Leach

Ahmed Hisham Wali

Tram Nguyen

Cade Fox

Gurinder Sandhu

Scott Harper

Jeffrey V Funderburk

Medical devices configured for in vivo assays of one or more analytes can sometimes be problematic if left inserted in a tissue, such as skin, for an extended time. Certain medical device surface profiles may aid in alleviating this issue. Accordingly, medical devices may comprise a base surface having a tissue-facing surface profile defined thereon, and a sensor extending through the base surface and at least a portion of the tissue-facing surface profile. The tissue-facing surface profile deviates from the base surface, and the tissue-facing surface profile is also configured to undergo a change in shape, hardness, or a combination thereof after contacting a tissue for a length of time. A dynamic material may be present in at least a portion of the tissue-facing surface profile.

Medical devices having a dynamic surface profile and methods for production and use thereof

The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.

NAD(P) depot for NAD(P)-dependent enzyme-based sensors

Provided are sensors and sensor applicator sets to insert at least a portion of an analyte sensor into a a skin surface of a subject, as well as methods of using the same.

Analyte sensing devices and methods

NADP-dependent oxidoreductase compositions, and electrodes, sensors and systems that include the same. Analyte sensors include an electrode having a sensing layer disposed thereon, the sensing layer comprising a polymer and an enzyme composition distributed therein. The enzyme composition includes nicotinamide adenine dinucleotide phosphate (NAD(P)) or derivative thereof; an NAD(P)-dependent dehydrogenase; an NAD(P)H oxidoreductase; and an electron transfer agent comprising a transition metal complex.

NAD(P)-dependent responsive enzymes, electrodes and sensors, and methods for making and using the same

A sensor control device and methods of making them are described. The sensor control device includes an electronics housing and a plug assembly. The electronics housing includes an upper shell matable to a lower mount having a skin-facing surface. The plug assembly is coupled to the electronics housing and includes a sensor module that has a sensor and a sharp module having a sharp. The plug assembly includes a base having a skin-facing surface and a plug portion comprising a lumen therethrough. At least a portion of a surface of the electronics housing or the plug assembly comprises an antimicrobial agent. The antimicrobial agent may be a metal and/or a metal oxide.

Antimicrobial and microstatic sensor systems

The present disclosure provides an analyte sensor for use in detecting aspartate and/or asparagine. In certain embodiments, an aspartate-responsive active site of a presently disclosed analyte sensor includes an aspartate oxidase disposed upon a surface of a working electrode. In certain embodiments, an asparagine-responsive active site of a presently disclosed analyte sensor includes an enzyme system comprising an aspartate oxidase and an asparaginase disposed upon a surface of a working electrode. The present disclosure further provides methods for detecting aspartate and/or asparagine using the disclosed analyte sensors.

Analyte sensors for detecting asparagine and aspartate and methods of use thereof

Techniques for data processing and control for a glucose monitoring system are provided, including obtaining a first sensitivity of a glucose sensor; obtaining a second sensitivity of the glucose sensor; comparing a difference between the first sensitivity and the second sensitivity to a predetermined range of values; if the difference is outside the predetermined range of the values, causing a calibration routine for the glucose sensor to be performed; and if the difference is within the predetermined range of values determining a composite sensitivity for a current calibration of the glucose sensor based on the first sensitivity and the second sensitivity and calculating the glucose level based on the current calibration of the glucose sensor.

Method and apparatus for providing data processing and control in a medical communication system

The present disclosure provides an analyte sensor for use in detecting potassium. In certain embodiments, an analyte sensor of the present disclosure includes at least two asparagine-responsive active areas, where each asparagine-responsive active area includes an asparaginase that exhibits a particular potassium dependency. In certain embodiments, an analyte sensor of the present disclosure includes at least two aspartate-responsive active areas, where each aspartate-responsive active area includes an aspartate oxidase that exhibits a particular potassium dependency. The present disclosure further provides methods for monitoring potassium levels, e.g., in vivo potassium levels, using the disclosed analyte sensors.

Continuous potassium sensors and methods of use thereof

Multiple analytes may be dysregulated singularly or concurrently in certain physiological conditions and may be advantageously assayed together using analyte sensors capable of detecting multiple analytes. Certain analyte sensors capable of the detection of multiple analytes may include first and second working electrodes, analyte-responsive active areas disposed on each of the working electrodes, and reference and counter electrodes. Analyte sensors that include multiple working electrodes but do not include reference and counter electrodes can also be used in conjunction with another sensor that contains reference and counter electrodes, such that these electrodes are shared.

Sensor array systems and methods for detecting multiple analytes

Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

Systems, devices and methods for analyte sensor insertion

A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.

Transcutaneous sensor with dual electrodes and methods of detecting and compensating for withdrawal of a transcutaneous sensor from a patient

Analyte sensor comprises an electrode layer having an elongate body comprising a proximal end and a distal end. The electrode layer includes a first active working electrode area, a second electrode portion, and at least one gap electrically separating the first active working electrode portion and the second electrode portion. The first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon. Additional analyte sensors disclosed.

Analyte sensors with reduced interferent signal and methods

Growing community of inventors

Oakland, CA, United States of America

Benjamin J Feldman