Medtronic Ardian Luxembourg S.a.r.l.

Intervene, Inc.

Ardian, Inc.

Medtronic Ireland Manufacturing Unlimited Company

Other

Medtronic Adrian Luxembourg S.a.r.l.

Cordis Corporation

Mjnn LLC

Lumend, Inc.

Medtronic Af Luxembourg S.a.r.l.

Benjamin J Clark

Denise Marie Zarins

Nicolas Zadno

Erik Thai

Mark Gelfand

Andrew H Wu

Hanson Gifford

Howard R Levin

Mark E Deem

Denise M Demarais

Mark S Leung

Kenneth J Michlitsch

Brian Kelly

Douglas Sutton

Grace Kelly

Roman Turovskiy

Stephen Nash

Karun D Naga

Eric Ryba

Naomi Buckley

Danny Donovan

Luke Hughes

Michi E Garrison

Maria G Aboytes

Fletcher T Wilson

John Kelly

Fiachra Sweeney

Lana Woolley

Michael Cummins

Barry Mullins

Vincenzo Tilotta

David Batten

Justin Goshgarian

Gary Kelly

Gwenda McMullin

Michael Turovskiy

Rajeshkumar Dhamodharasamy

William R George

Gwenda Francis

Daniel Cook

Nathaniel R Storey

Neil Chand Barman

Sergio Salinas

Robert J Beetel

Michael E Duffy

David J Hobbins

Jaremy Creechley

Nate Mazonson

Gary P Kelly

Seamus Ledwith

Rob Jensen

Matthew Barnard

Matteo Melani

Tim Huynh

Jack Oslan

Philip E Beatty

John L Whitcher

Christopher K Conway

Ernest Learn

Russell Varone

Russell Field

Hanson S Gifford, Iii

Luke W Clauson

Kent D Dell

Robert K Deckman

David J Kupiecki

Matthew R Selmon

Kurt D Sparks

Brent Seybold

Sowmya Ballakur

Francesco Piccagli

David Lari

Kurt Sparks

Herbert M Mendoza

John Paul Sam

Amiel R Aguilar

Daniel E Francis

Jeffrey L Emery

C Danielle Pinson

Allen W Madsen

Michael D Keleher

Emmanuelle F Pease

Andrew Wu

Lana Wooley

Denise Zarins

Denise Demarais

David Hobbins

Mark Deem

Hanson Iii Gifford

Stephen Naash

Gwenda Mcmullin

The present technology is directed generally to devices, systems, and methods for capturing and cutting fibrous and trabeculated structures (such as synechiae) in vessel lumens. In one embodiment, the present technology includes an intraluminal tissue modifying system configured to capture the fibrous structures, put the fibrous structures in tension, and controllably cut through the fibrous structures without applying appreciable additional force to the vessel wall. The system may include an expandable capture device and a cutting device.

Intraluminal tissue modifying systems and associated devices and methods

Methods and apparatus are provided for pulsed electric field (PEF) neuromodulation via an intra-to-extravascular approach, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation and other conditions in target neural fibers. In some embodiments, an apparatus includes an intravascular catheter having one or more electrodes configured for intra-to-extravascular placement across a wall of patient's vessel into proximity with target neural fibers. With the electrode(s) passing from an intravascular position to an extravascular position prior to delivery of the PEF, a magnitude of applied voltage or energy delivered via the electrode(s) and necessary to achieve desired neuromodulation may be reduced relative to an intravascular PEF system having one or more electrodes positioned solely intravascularly. The methods and apparatus may, for example, be used to modulate one or more target neural fibers that contribute to renal function.

Methods and apparatus for pulsed electric field neuromodulation via an intra-to-extravascular approach

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Neuromodulation cryotherapeutic devices and associated systems and methods

Methods and system are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

Devices for thermally-induced renal neuromodulation

Endovascular valve formation systems with imaging capabilities and associated devices and methods are disclosed herein. In some embodiments, a valve formation and imaging system can include, for example, (i) a valve formation device configured to access a vessel wall and dissect a portion of the vessel wall to form an autologous valve leaflet and (ii) an imaging device configured to image the vessel wall and components of the valve formation device during a valve formation procedure. In some embodiments, the imaging device is integrated into a distal end portion of the valve formation device. In some embodiments, the imaging device is a separate catheter device positionally coupled to the valve formation device and/or components thereof.

Endovascular valve formation system with imaging capability

Cryotherapeutic devices for renal neuromodulation and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having a distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator having a distributor in fluid communication with the supply lumen and a balloon configured to deliver cryotherapeutic cooling to nerves proximate the treatment site when the cooling assembly is in a deployed state.

Cryotherapeutic devices for renal neuromodulation and associated systems and methods

Apparatus, systems, and methods for achieving thermally-induced renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a thermal element to a renal artery via an intravascular path. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers.

Apparatus, systems, and methods for achieving intravascular, thermally-induced renal neuromodulation related application

Catheter assemblies for neuromodulation proximate a renal artery bifurcation and associated systems and methods are disclosed herein. A catheter assembly configured in accordance with a particular embodiment of the present technology can include a shaft having a proximal portion, a distal portion, and two therapeutic arms extending from the distal portion. The shaft can be configured to deliver the distal portion to a treatment site proximate a branch point or bifurcation in a renal blood vessel. The therapeutic arms can include energy delivery elements that are configured to deliver the therapeutically-effective energy to renal nerves proximate the branch point.

Catheter assemblies for neuromodulation proximate a bifurcation of a renal artery and associated systems and methods

A computer implemented system for a vertical farming system comprising at least a first crop growth module and operating in an environmentally-controlled growing chamber, the control system comprising sensors for measuring environmental growing conditions in the environmentally-controlled growing chamber over time to generate environmental condition data, a device configured for measuring a crop characteristic of a crop grown in the crop growth module of the environmentally-controlled growing chamber to generate crop growth data and a processing device comprising software modules for receiving the environmental condition data and the crop growth data; applying an algorithm to the environmental condition data and the crop growth data to generate an improved environmental growing condition and generating instructions for adjustment of the environmental growing conditions in or around the growth module in the environmentally-controlled growing chamber to the improved environmental growing condition.

Control and sensor systems for an environmentally controlled vertical farming system

Growing community of inventors

Redwood City, CA, United States of America

Benjamin J Clark