University of Florida Research Foundation Inc

Vanderbilt University

Benjamin George Keselowsky

Abhinav Prakash Acharya

Michele Viola Manuel

Malisa Sarntinoranont

Harpreet Singh Brar

Jamal Lewis

Hunter B Henderson

Michael J Clare-Salzler

Edward William Scott

Emina Huang

Ida E Svensson Berglund

Matthew Carstens

Craig L Duvall

Mark A Atkinson

Clive Henry Wasserfall

Ida Svensson Berglund

Brian Connor Evans

Margaret Mary Fettis

Todd M Brusko

Lawrence Premasiri Fernando

Lirong Yang

Sabrina Freeman

Antonietta Restuccia

Shaheen Farhadi

Evelyn R Bracho-Sanchez

Dorina Avram

Joshua Stewart

Young Mee Yoon

Jonathan Joseph Cho

Judit Cserny

Gregory Hudalla

Embodiments of the present disclosure provide for structures including an alloy of calcium, strontium, and magnesium.

Bioresorbable metal alloy and implants

Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosable and non-phagocytosable microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant to a subject suffering from Multiple Sclerosis to generate tolerogenic dendritic cells in the subject and treat the Multiple Sclerosis.

Microparticle systems and their use for the treatment of multiple sclerosis

Provided herein are targeted effector fusion proteins, complexes thereof, and uses thereof. The targeted effector fusion proteins can include an effector protein that can be linked to a targeting moiety. Monomer targeted effector fusion proteins can form homogeneous or heterogeneous complexes. The targeted effector fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted effector fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.

Targeted effector proteins and uses thereof

The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.

Antigen-specific, tolerance-inducing microparticles and uses thereof

Embodiments of the present disclosure include particles, methods of making particles, methods of delivering an active agent using the particle, and the like.

Polymeric particles, method for cytosolic delivery of cargo, methods of making the particles

The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.

Materials and methods for modulating immune responses

The present invention provides nanoparticle-coupled tolerogenic Treg cell therapy for treatment of immune and/or autoimmune disorders. In certain specific embodiments, the present invention can be used in the prevention and/or treatment of autoimmune diseases including, but not limited to, type 1 diabetes, lupus erythematosus (SLE), multiple sclerosis (MS), inflammatory bowel disease (IBD), rheumatoid arthritis, oophoritis, and autoimmune pathology associated with Graft versus Host Disease (GvHD) following hematopoietic stem cell transplantation.

Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.

Bioresorbable metal alloy and implants made of same

Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.

Cell-based arrays, methods of making, and methods of using

Embodiments of the present disclosure provide for arrays, systems, and methods for the analyzing cells, methods of making arrays, and the like.

Growing community of inventors

Gainesville, FL, United States of America

Benjamin George Keselowsky