General Electric Company

Tokitae LLC

Benjamin David Grant

Bernhard Hans Weigl

John Richard Nelson

Paul Michael Smigelski, Jr

David Roger Moore

Matthew Jeremiah Misner

Gregory Andrew Grossmann

Cathryn Ellen Olsen

John Thomas Connelly

Kevin Paul Flood Nichols

Joshua Davis Bishop

Toan Huynh

Damian Madan

Caitlin E Anderson

David Michael Cate

A device for rapid detection of a tuberculosis lipoarabinomannan (TB-LAM) is provided. The device includes a pre-concentrator unit for concentrating the TB-LAM comprising: an ion-exchange medium comprising one or more ligands configured to capture the TB-LAM from the source biological sample, wherein the captured-TB-LAM is eluted from the ion-exchange medium as an eluate comprising a concentrated form of TB-LAM; a cassette; a lateral flow assay unit disposed in the cassette; and an integration unit attached to the pre-concentrator unit and the cassette. The integration unit is configured to operatively couple and de-couple the pre-concentrator unit and the cassette. The pre-concentrator unit and the lateral flow assay unit disposed in the cassette are in a fluidic communication in a coupled form. The device for rapid detection of TB-LAM further comprises a dilutor unit.

Device for rapid detection of tuberculosis-lipoarabinomannan (TB-LAM) with enhanced sensitivity

Embodiments include assay devices within a single use, disposable cassette for biochemical assays with at least one fluid well and at least one capillary valve. The capillary valve in combination with motion of porous sheets within the assay leads to addition of liquid reagents at different times to the assay although a user adds the liquid reagents to the cassette simultaneously.

Assay structures for multi-step biochemical assays

Growing community of inventors

Bellevue, WA, United States of America

Benjamin David Grant