Harvard College

Other

Benjamin D Pope

Kevin Kit Parker

Aaron L Glieberman

Nina R Sinatra

Alanna R Gannon

Kevin L Shores

The present invention provides methods and systems which accommodate 3-dimensional adipocyte expansion to produce, e.g., mature adipocytes and synthetic adipose tissue with cellular properties of mature adult organisms, including cell size and cytoarchitecture, and the use of such methods and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications.

Methods for producing mature adipocytes and methods of use thereof

Microfluidic systems including a housing configured to receive a cartridge, the cartridge including a plurality of wells for receiving one or more biological cells are described herein. The microfluidic systems include a structure with channels for introducing a medium into the housing and through channels the cartridge. Microfluidic systems including a housing configured to receive a cartridge, the housing including channels for loading one or more biological cells within wells of the cartridge are described herein. Three-dimensional scaffolds, devices, and systems comprising such scaffolds that mimic the in vivo structure, physical properties, and protein composition of extracellular matrix surrounding pancreatic islet cells and adipocytes, and the use of such compositions, devices and systems for, e.g., in vitro drug screening and/or toxicity assays, disease modeling, and therapeutic applications are also described herein.

Cartridge-based system for long term culture of cell clusters

Toy castle

A modular model building structure comprising an integrally-formed base and a plurality of modular units. The modular units are formed so as to fixedly contact with the base with other modular units of the model structure. Further, the modular units are interchangeable, in part, thereby allowing the model structure to be arranged in several alternative configurations.

Modular model structure

Growing community of inventors

Medford, MA, United States of America

Benjamin D Pope