Massachusetts Institute of Technology

Children's Medical Center Corporation

Benjamin C Tang

Robert Samuel Langer

Daniel Griffith Anderson

Arturo Jose Vegas

Yizhou Dong

Omid Veiseh

Eric Andrew Appel

Yunlong Zhang

Rosemary Lynn Kanasty

Matthew J Webber

Weiheng Wang

Hung-Chieh Chou

Michael J Webber

Yair Levi

Kun Xue

Described herein are polymers, polymeric gels, or a composition thereof, for drug delivery. The polymers, which include boronic-acid containing moieties (e.g., and polyol-containing moieties (e.g., are prepared by free-radical polymerization and can self-assemble into polymeric gels such as hydrogels. Also provided are methods or preparing the polymers, kits involving the polymers and/or polymeric gels or a composition thereof, for use as materials or delivery applications of an agent to a subject.

Polymers, hydrogels, and uses thereof

Compounds, compositions, and methods for 'smart' delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

Insulin derivatives for diabetes treatment

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Cambridge, MA, United States of America

Benjamin C Tang