Flagship Pioneering Innovations Vii, LLC

Benjamin Andrew Portney

Geoffrey Von Maltzahn

Jacob Rosenblum Rubens

Molly Krisann Gibson

Narahari Subbanna Pujar

Alexandra Rachael Sneider

Camilo Ayala Breton

The disclosure provides, for example, single stranded, covalently closed DNA that does not form a double stranded structure longer than 100 base pairs. The ssDNA may encode an effector sequence, for instance a therapeutic protein. The ssDNA may comprise a nuclear targeting sequence (NTS). In some embodiments, the ssDNA shows decreased activation of the innate immune system compared to an otherwise similar dsDNA.

Growing community of inventors

Somerville, MA, United States of America

Benjamin Andrew Portney