Ensemble Therapeutics Corporation

Dsm Nutritional Products Inc.

Cadena Bio, Inc.

Benjamin A Seigal

Scott S Han

Robert Michael Borzilleri

Yong Zhang

John M Geremia

Atli Thorarensen

Li Huang Xing

Jinbo Lee

Michael Matthew Miller

Kyle Sherry

Stephen Paul Hale

Frank G Favaloro, Jr

Andrew O'Connor

Timothy F Briggs

Nicholas K Terrett

Devin Churchman

Stephen Panos

Alicia Landry

Andrew O'connor

Julian F Bond

Kelley C Shortsleeves

Anastasia V Murphy

Anastasia V Lioubomirov

Cheri Snedeker

Wei-Chuan Sun

Daniel Wang

Sethu L Alexander

Dingxue Yan

Tyler J Cipriani

William H Connors

Michael Taylor

Scott Han

Described herein are methods for the production of oligosaccharides, including functionalized oligosaccharides, from one or more sugars, such as one or more monosaccharides, using polymeric and solid-supported catalysts containing acidic and ionic groups. Also provided are the oligosaccharide compositions, including functionalized oligosaccharide compositions, obtained using the methods.

Oligosaccharide compositions and methods for producing thereof

The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions, such as inflammatory diseases and other IL-17-associated disorders. 

Macrocyclic compounds for modulating IL-17

Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

Macrocyclic compounds for inhibition of tumor necrosis factor alpha

Growing community of inventors

Newton, MA, United States of America

Benjamin A Seigal