Genentech, Inc.

Beni B Wolf

Avi J Ashkenazi

Daniel P Sutherlin

Germaine G Fuh

Jo-Anne Hongo

Frederick Cohen

Wayne J Fairbrother

Chingwei Vivian Lee

Dorothy French

Gretchen Frantz

Robert Maurice Pitti

Liliana Soroceanu

David A Eberhard

Heidi Ackerly

Scot A Masters

Evgeny Varfolomeev

Clifford Quan

Helga A Raab

The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.

Compositions and methods relating to STOP-1

Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. 

Fibroblast activation protein inhibitor compounds and methods

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Redwood City, CA, United States of America

Beni B Wolf