Astrazeneca Ab

Astra Aktiebolag

Bengt Ulff

Svante Bertil Ross

Seth-Olov Thorberg

Stefan Berg

Mats Torbjorn Linderberg

Sven E Hellberg

David Jackson

Gerd Hallnemo

Lian Zhang

Nina Mohell

Substituted 1,2,3,4-tetrahydronaphthalene derivatives

The present invention relates to new piperidinyl- or piperazinyl-substituted-3,4-dihydro-2H-1-benzopyran derivatives having formula (I) wherein X is N or CH; Y is NR CH , CH NR , NR CO, CONR or NR SO wherein R is H or C -C alkyl; R is H, C -C alkyl or C -C cycloalkyl; R is C -C alkyl, C -C cycloalkyl or (CH ) -aryl, wherein aryl is phenyl or a heteroaromatic ring containing one or two heteroatoms selected from N, O and S and which may be mono- or di-substituted; n is 0-4; R is C -C alkyl, C -C cycloalkyl, OCF , OCHF , OCH F, halogen, CONR R , CN, CF , OH, C -C alkoxy, NR R , SO CH , SO CF , SO NR R , an unsubstituted or substituted heterocyclic or heteroaromatic ring containing one or two heteroatoms selected from N and O, wherein the substituent(s) is(are) C -C alkyl; or COR ; wherein R , R and R are as defined above, as (R)-enantiomers, (S)-enantiomers or racemates in the form of a free base or pharmaceutically acceptable salts or solvates thereof, a process for their preparation, pharmaceutical compositions containing said therapeutically active compounds and to the use of said active compounds in therapy.

Substituted chroman derivatives

Intermediates in the preparation of substituted chroman derivatives

The present invention relates to new piperidyl- or piperazinyl-substituted-1,2,3,4-tetrahydronaphthalene derivatives having the formula I

Phenylethyl and phenylpropylamines

Growing community of inventors

Södertälje, Sweden

Bengt Ulff