Kabivitrum Ab

Apoteksvarucentralen Vitrum Ab

Kabi Pharmacia Aktiebolag

International Nutritional Research Institute Ab

Bengt M Ajaxon

Karl A Wretlind

Arvid Wretlind

Stellan Ljungberg

Ivan Hakansson

Arvid K Wretlind

Emulsion for parenteral administration

Triglyercide nutrient for humans and animals

The invention concerns fat emulsion for intravenous adminstration for nutritive, diagnositic or therapeutic purposes, or for tissue culture and storage or organ transplants. According to the invention, the emulsion contains one or more substances preventing or retarding aggregation or agglutination ('creaming') when the emulsion is mixed with blood, serum or plasma.

Fat emulsions

The invention relates to an emulsion for use as an X-ray contrast agent and containing one or more iodinated lipids emulsified in an aqueous phase. The emulsion contains one or more amino acids, fatty acids or their salts, fat-soluble vitamins and/or urea for increasing its stability. Furthermore, the emulsion may contain one or more pharmacologically acceptable oils or fats. By the stability-increasing agent, it has been possible to prepare emulsions of iodinated lipids which can be sterilized in an autoclave and be stored for a long time without the emulsion breaking.

Iodine-containing emulsion

According to the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.

Composition for enhancing the administration of pharmacologically active

According to the method of the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.

Method of enhancing the administration of pharmalogically active agents

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Uppsala, Sweden

Bengt M Ajaxon