Lytix Biopharma As

Bengt Erik Haug

John Sigurd Svendsen

Øystein Rekdal

Wenche Stensen

Morten Bøhmer Strøm

Istvan Marko

Merete Linchausen Skar

Jon Amund Eriksen

Oystein Rekdal

ØYstein Rekdal

Morten Böhmer Ström

The present invention relates to peptides or peptide like molecules and their uses in therapy, in particular as anti-tumor agents.

Nonapeptide with anti-tumour activity

The invention provides a method of treating tumors by adminstering to a human or animal patient an effective amount of a molecule of 2 to 4 amino acids or equivalent subunits in length, which incorporates a bulky and lipophilic group comprising at least 13 non-hydrogen atoms and containing no more than 2 polar functional groups, in which the bulky and lipophilic group incorporates one or more closed rings of 5 or more non-hydrogen atoms, and in which the molecule further has at least two more cationic than anionic moieties.

Method of treating tumors

The invention relates to the use of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto at least two bulky and lipophilic groups and having at least one more cationic than anionic moiety, in the manufacture of a medicament for destabilizing microbial cell membranes and the use as a membrane acting antimicrobial agent of a molecule comprising a backbone of 2 to 35 non-hydrogen atoms in length, having covalently attached thereto a super bulky and lipophilic group comprising at least 9 non-hydrogen atoms and having at least two more cationic than anionic moieties and to methods of treatment involving such molecules, in particular peptides including peptide derivatives, and peptidomimetics.

Antimicrobial compounds and formulations

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Tromsø, Norway

Bengt Erik Haug