Lytix Biopharma As

Bengt Erick Haug

John Sigurd Svendsen

Wenche Stensen

Oystein Rekdal

The present invention relates to a compound of formula (I) AA-AA-AA-X&#x2014;Y&#x2014;Z wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; X is a N atom, which may be substituted by a branched or unbranched C-Calkyl or aryl group which group may incorporate up to 2 heteroatoms selected from N, O and S; Y represents a group selected from &#x2014;R&#x2014;R&#x2014;, &#x2014;R&#x2014;R&#x2014;R&#x2014; and &#x2014;R&#x2014;R&#x2014;R&#x2014; wherein Ris C, O, S or N, and Ris C; each of Rand Rmay be substituted by C-Calkyl groups or unsubstituted; and Z is a group comprising 1 to 3 cyclic groups each of 5 or 6 non-hydrogen atoms, 2 or more of the cyclic groups may be fused and one or more of the cyclic groups may be substituted; the Z moiety incorporates a maximum of 15 non-hydrogen atoms; and wherein the bond between Y and Z is a covalent bond between Ror Rof Y and a non-hydrogen atom of one of the cyclic groups of Z. The invention further relates to formulations containing these compounds and their uses in therapy, particularly as antimicrobial or antitumoural agents.

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Tortnes, Norway

Bengt Erick Haug