Mitra Medical Technology Ab

University of Washington

Glycorex Transplantation Ab

Bengt E B Sandberg

Rune Nilsson

D Scott Wilbur

A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.

Trifunctional reagent for conjugation to a biomolecule

The present invention provide methods to improve the treatment of cancer in mammals, including ovarian cancer, where intraperitoneal administration of cytotoxic medical agents or immunoconjugates are utilized. The invention provides means of substantially reducing the level of cytotoxic medical agents or immunoconjugates in the circulating blood. Hence, the organ exposure of circulating cytotoxic agents is minimized using the invention and the invention offers opportunities to use more effective dose treatment regime.

Targeting of biomolecules

An apparatus for use in connection with removal of elements, especially exogenous antibodies, from blood or plasma flowing in an extracorporeal blood circulation system of a patient, where said apparatus comprises a container ( ). This container is adapted to receive an adsorbent and comprises an inlet ( ) and an outlet ( ) which are adapted to be connected to an inlet conduit ( ) and an outlet conduit ( ), respectively, forming part of the blood circulation system. The container ( ) comprises an inlet chamber ( ), an adsorption chamber ( ) adapted to receive the adsorbent, and an outlet chamber ( ). These chambers are arranged in sequence when seen in the flow direction of the blood or the plasma through the container ( ) and are separated by means of filter units ( ) allowing passage of the blood or the plasma. The inlet ( ) and the outlet ( ) are arranged adjacent one another in connection with a common movable valve means ( ). The valve means is adapted so as in a first position to connect the inlet ( ) and the outlet ( ) directly with their respective passages ( ) in the container wall ( ) and so as in a second position to connect said inlet ( ) and said outlet ( ) with their respective ends of a bypass-forming channel ( ) in the container wall ( ). The passage ( ) associated with the inlet communicates with a transfer channel ( ) ending in the inlet chamber ( ), whereas the passage ( ) associated with the outlet ( ) is open into the outlet chamber ( ).

Growing community of inventors

Hjärup, Sweden

Bengt E B Sandberg