Other

Pharmacia Ab

Aktiebolaget Leo

Kabi Pharmacia Ab

Bengt C Sjogren

Sven-Borje Andersson

Inga M Lindskog

Lennart G Nordh

Nils-Erik Willman

Gustav L Persson

Goran H Sjoholm

##STR1## Compounds of formula (I) and their physiologically acceptable salts thereof, their use as therapeutical substances, pharmaceutical compositions containing them, and methods for preparing the compounds.

Pharmacologically active alpha-[tertiary-aminomethyl]-benzenemethanol

The invention concerns an intravaginal device comprising a combination of 17.beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continously 17.beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.

Intravaginal devices

The invention concerns an intravaginal device comprising a combination of 17 .beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continuously 17 .beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.

The invention concerns: Novel dibenz/b,e/oxepin and dibenz/b,e/thiepin compounds having the general formula: ##STR1## wherein X is O or S,

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Viken, Sweden

Bengt C Sjogren