Teva Pharmaceuticals International Gmbh

Nsab, Filial Af Neurosearch Sweden Ab

Volvo Technology Corporation

Bengt Andersson

Clas Sonesson

Susanna Waters

Joakim Tedroff

Nicholas Ross Waters

Ingela Marianne Svan

Nicholas Waters

Martin Petersson

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1), wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; Ris OSOCF, OSOCH, SOR, SOR, COR, NO, or CONHRand when X is CH or C Rmay also be CF, CN, F, Cl, Br, or I; Ris a C-Calkyl, an allyl, CHSCH, CHCHOCH, CHCHCHF, CHCF, 3,3,3-trifluoropropyl, 4,4,4,-trifluorobutyl, or &#x2014;(CH)&#x2014;R; Ris a C-Calkyl CF, or N(R); Ris a C-Ccycloalkyl, 2-tetrahydrofurane or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed

Modulators of dopamine neurotransmission

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula (1) wherein X is N, CH, or C, however X may only be C when the compound comprises a double bind at the dotted line; Ris CF, OSOCF, OSOCH, SOR, SOR, COR, CN, OR, NO, CONHR, 3-thiophene, 2-thiophene, 3-furane, 2-furane, F, Cl, Br, or I; Ris F, Cl, Br, I, CN, CF, CH, OCH, OH, and NH; Rand Rare independently H or a C-Calkyl; Ris a C-Calkyl, an allyl, CHSCH, CHCHOCH, CHCHCHF, CHCF, 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or &#x2014;(CH)R; Ris a C-Ccycloalkyl, 2-tetrahydrofurane, or 3-tetra-hydrofurane; Ris a C-Calkyl, CF, or N(R), and pharmaceutically acceptable salts thereof are disclosed. Also pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.

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Göteborg, Sweden

Bengt Andersson