Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Beng Poon Teng

Christophe Thurieau

Eric Ferrandis

Christine Sohier

Olivier Lavergne

Christophe Lanco

Grégoire Prevost

A method of treating cancer dependent on growth factor GHRH in warm-blooded animals in need thereof with an isolated protein extended for

Heterocarpine, a plant-derived protein with anti-cancer properties

The invention relates to a human GHRH-binding protein (human Growth Hormone-releasing hormone). Said protein, which is obtained from theplant, can be used to prepare medicaments intended to antagonise the effects of GHRH and to treat proliferative diseases (particularly cancer), acromegaly or diabetic nephropathies and retinopathies.

Heterocarpine, a human GHRH-binding protein

A process for the preparation of an extract ofleaves, comprising

Method for preparing an extract of ginkgo biloba leaves highly enriched in active principles

The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general formula (1) corresponding to general sub-formulae (I)and (I), wherein: Rrepresents H, SRor NRR; Rrepresents SRor NRR; Rrepresents OH, O(CO)R, OSiRRR, O(CO)ORor O(CO)NHR, each of the radicals R, R, R, Rand Rrepresenting independently (in particular) an alkyl radical, the radicals Rand Rrepresenting (in particular) radicals selected independently among a hydrogen atom and an alkyl radical, and each of the radicals Rand Rrepresenting independently (in particular) an alkyl or cycloalkyl radical, or one among aryl, heteroaryl, aralkyl or heteroalkyl radicals optionally substituted; provided that when the compounds correspond to the general sub-formula (I), then Rdoes not represent a hydrogen atom

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Gif-sur-Yvette, France

Beng Poon Teng