Tufts University

The Royal Institution for the Advancement of Learning / Mcgill University

Mcgill University

Benedetto Marelli

Fiorenzo G Omenetto

David L Kaplan

Hu Tao

Miaomiao Yang

Mark A Brenckle

Showan Nazhat

Sunghwan Kim

Alexander Nicholas Mitropoulos

Jake E Barralet

Antonio Alessandrino

Giuliano Freddi

Chiara Ghezzi

Neysan Nejat Oliver Kamranpour

Showan N Nazhat

Neysan Nejat Kamranpour

The present application relates to silk fibroin-based hydrogels, methods for making and using the same.

Optically transparent silk hydrogels

Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.

Biopolymer-based preservation of perishable products

The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as 'green' resists.

All water-based nanopatterning

The present application discloses biopolymer-based ink formulations that are useful for inkjet printing and other applications. Related methods are also disclosed.

Biopolymer-based inks and use thereof

Disclosed herein are nanofibrillar materials and aerogel-like materials comprised of nanofibrils, and methods for making such materials.

Peptide-based nanofibrillar materials

The present invention provides compositions and methods for printing a predetermined pattern on silk fibroin materials using water based 'inks.' Such technique may be useful for micro- and nano-engineering applications.

Silk water lithography

A method for making a biomaterial comprising providing at least one polypeptide fraction chymotryptically isolated and extracted from fibroin, and adding the at least one extracted polypeptide fraction to a hydrogel precursor before gelling, wherein the at least one isolated and extracted polypeptide fraction is selected from a soluble fraction Cs, and a precipitated fraction Cp. A biomaterial comprising at least one of the isolated and extracted polypeptide fractions incorporated in a hydrogel or a hydrogel precursor. Use of the biomaterial for constructing, regenerating, repairing, replacing or augmenting soft or hard tissue; as an in vitro or in vivo construct; as a coating material; or as a cell, molecule or particle delivery medium. Use of the isolated and extracted polypeptide fraction Cs for promoting osteoinduction, osteoconduction or osteogenesis. Use of the isolated and extracted polypeptide fraction Cp for enhancing a mechanical compressive modulus of a material into which it is incorporated.

Biomaterial of chymotryptically isolated fraction of fibroin in a hydrogel

There is provided a method for preparing a dense hydrogel comprising providing an at least partially gelled hydrogel, placing the at least partially gelled hydrogel in fluid communication with an end of a capillary, and driving the at least partially gelled hydrogel into the capillary to form a dense hydrogel. There is also provided a system for preparing the dense hydrogel comprising a capillary having a bore; and a driver in communication with an end of the capillary for driving an at least partially gelled hydrogel into the bore of the capillary to form a dense hydrogel.

Growing community of inventors

Somerville, MA, United States of America

Benedetto Marelli