Fondazione Istituto Italiano Di Tecnologia

Giuliani S.p.a.

Benedetto Grimaldi

Tiziano Bandiera

Rita Scarpelli

Giovanni Bottegoni

Esther Torrente

Marina Veronesi

Sergio Baroni

Giammaria Giuliani

Barbara Marzani

Ralf Paus

The invention relates to a synergistic composition comprising a dry extract of plant of genusand a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

Synergistic composition as a promoter of autophagy

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof:  It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.

Diarylalkylamine REV-ERB antagonists and their use as medicaments

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy. 

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Genoa, Italy

Benedetto Grimaldi