Fresenius Medical Care Deutschland Gmbh

Unicyte Ev Ag

Children's Hospital Los Angeles

Bussolati, Benedetta

Benedetta Bussolati

Giovanni Camussi

Maria Beatriz Herrera Sanchez

Stefania Bruno

Maria Chiara Deregibus

Roger De Filippo

Laura Perin

Tatiana Lopatina

Stefano Buttiglieri

Veronica Dimuccio

Sargis Sedrakyan

A method for treating renal cancer by administering a pharmaceutically acceptable carrier comprising a microRNA selected from the group consisting of miR-15a, miR-181b, miR-320c, miR-874 and any combination thereof is provided. In an embodiment, the pharmaceutically acceptable carrier is an extracellular vesicle (EV) derived from an adult stem cell selected from the group consisting of a mesenchymal stem cell (MSC), a non-oval human liver progenitor cell (HLSC) and an adipose stem cell (ASC).

Pharmaceutical carriers containing miRNAs for use in the treatment of renal cancer

The invention relates to an isolated multipotent glomerular mesenchymal stem cell derived from adult human kidney (hGL-MSC), which is characterized by the marker profile CD133, CD146, CD34and CD105. A method of preparing the hGL-MSC of the invention form decapsulated glomeruli is also disclosed, as well as the uses of the hGL-MSC of the invention in the regenerative treatment of the kidney, particularly for the treatment of injuries or diseases affecting renal glomeruli.

Isolated multipotent mesenchymal stem cell from human adult glomeruli (HGL-MSC), a method of preparing thereof and uses thereof in the regenerative medicine of the kidney

The invention relates to human liver pluripotent progenitor cell lines which express hepatic cell markers such as albumin and &#x3b1;-fetoprotein and do not express some of the markers which are typical of oval stem cells. Also disclosed is a method of isolating the cell lines of the invention, methods for differentiating said cells into a plurality of different cell lineages, methods for conditional immortalization and metabolic selection of said cells, as well as the use of the cell lines of the invention for preparing a medicament with osteogenic differentiation activity or liver injury regeneration activity.

Liver progenitor cells

Growing community of inventors

Turin, Italy

Benedetta Bussolati