Ge Healthcare Limited

Bayer Healthcare Aktiengesellschaft

Ge Healthcare As

Bayer Pharma Aktiengesellschaft

Intermed Discovery Gmbh

Ben Newton

Rainer Endermann

Thomas Lampe

Josef Pernerstorfer

Jens Pohlmann

Christoph Freiberg

Mitsuyuki Shimada

Nina Brunner

Guido Schiffer

Michael Otteneder

Mikkel Jacob Thaning

Peter Nell

Magne Solbakken

Niels Svenstrup

Rajiv Bhalla

Peter Brian Iveson

Salah Chettibi

Uwe Petersen

Harald Labischinski

Bard Indrevoll

Edvin Wilhelm Johannesen

Mette Husbyn

Dirk-Jan In't Veld

Jane Brown

Bård Indrevoll

Lars-Göran Wistrand

Karina Langseth

Christoph Ladel

Daniel Kramer

Paul Michael Evans

Lars-Goeran Wistrand

Mitsuyuki 905 Laurel Court Nara Minami Shimada

The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.

X-ray imaging contrast media with low iodine concentration and X-ray imaging process

The present invention relates to technetium imaging agents comprising radiolabeled c-Met binding peptides suitable for SPECT or PET imaging in vivo. The c-Met binding peptides are labelled via chelator conjugates. Also disclosed are pharmaceutical compositions, methods of preparation of the agents and compositions, plus methods of in vivo imaging using the compositions, especially for use in the diagnosis of cancer.

Technetium labelled peptides

The present invention relates to a method useful in facilitating the identification of fibrogenesis in a subject. The method of the invention is particularly useful when applied as part of a method to diagnose fibrogenesis of the liver. The invention also provides a compound for use in a method for identification of fibrogenesis in a subject A further aspect of the invention is a compound for use in the preparation of a medicament for use in a method for identification of fibrogenesis in a subject.

Imaging method

The present invention relates to a new diagnostic X-ray composition which exhibits a superior cardiac safety profile. The composition comprises a non-ionic iodinated dimer in a pharmaceutically acceptable carrier. More particularly, the invention provides a diagnostic composition comprising a Compound I, a pharmaceutically acceptable carrier, and dissolved therein a sodium compound and a calcium compound providing a sodium ion concentration of 40-50 mM and a calcium ion concentration of 0.1-0.7 mM. The invention also relates to methods of imaging using such diagnostic compositions. 

Diagnostic composition comprising plasma cations having superior safety profile

The present invention provides a novel imaging agent suitable for the non-invasive visualization of fibrosis. A precursor for the preparation of the imaging agent is also provided by the invention, as well as a pharmaceutical composition comprising the imaging agent and a kit for the preparation of the pharmaceutical composition. In a further aspect, use of the imaging agent for in vivo imaging and in the preparation of a medicament for the diagnosis of a condition which comprises fibrosis is provided.

Imaging agents

The invention relates to inhalable quinolonecarboxylic acid derivative compositions for local control of diseases of the respiratory organs, in particular of lung diseases.

Treatment of bacterial diseases of the respiratory organs

The invention relates to compounds of general formula (I), to a method for the production thereof, to pharmaceutical compositions containing them, and to their use in the treatment and/or prophlaxis of diseases in humans or animals, particularly bacterial infections diseases. The compounds are derivatives of the natural substances andrimide and moiramide B.

Derivatives of andrimide and moiramide B having antibacterial properties

The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in people or animals, especially diseases of bacterial infection.

Cinnamic acid amides

The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.

Arylamides

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Amersham, United Kingdom

Ben Newton