Dsm N.v.

Centrient Pharmaceuticals Netherlands B.v.

Ben Lange De

Quirinus B Broxterman

Harold Monro Moody

Bernardus Kaptein

Wilhelmus Hubertus Joseph Boesten

Johannes Paulus Gerardus Seerden

Marcelles Van Der Sluis

Robertus Mattheus Pater De

Process for the preparation of a diasteromerically enriched phenylglycine amide derivative in which an enantiomerically enriched phenylglycine amide is converted into the corresponding Schiff base with the aid of compound R &mdash;C(O)&mdash;R , and the Schiff base obtained is subsequently converted into the diastereomerically enriched phenyglycine amide derivative with the aid of a cyanide source, a reducing agent or an allyl organometallic compound. The phenylglycine amide derivatives obtained are interesting starting materials for the preparation of for example enantiomerically enriched &agr;- and or &bgr;-amino acids and derivatives thereof, such as amides and esters, and amines.

Method for the preparation of enantiomerically enriched compounds

Growing community of inventors

Munstergeleen, Netherlands

Ben Lange De