Beiersdorf Ag

Ben Armah

Erich Cohnen

Wolfgang Stenzel

Theo Schotten

Michael Paal

Wolfgang Fleck

Eva Hofferber

Thomas Beuttler

Vera Planitz

Reinhard Bruckner

Compounds for the treatment of cardiac insufficiency, an arterial thrombo embolism, an arterial occlusive disease, psoriasis, neurodermatitis, asthma, platelet aggregation and hypertension, of the formula ##STR1## in which R.sub.1 is hydrogen, C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.3-7 -cycloalkyl,

Cardioactive pyrrolobenzimidazoles

Indolylpropanols of the formula I ##STR1## in which R.sup.1 and R.sup.2, which can be identical or different, in each case denote a 2-, 3- or 4-pyridinyl or a 2- or 3-thienyl radical, phenyl or phenyl which is optionally monosubstituted or identically or differently disubstituted by halogen, alkyl, C.sub.3-7 -cycloalkyl or C.sub.1-6 -alkoxy, where alkyl denotes straight-chain alkyl having 1 to 6 carbon atoms or branched alkyl having 3 to 6 carbon atoms, and their salts and acid addition salts, tautomers and optical isomers show positive inotropic and antiarrhythmic activity.

Indolylpropanols and preparations containing the compounds

Benzopyran derivatives of the general formula I ##STR1## wherein the substituents are as defined herein are provided. The compounds show vasodilating and vascular spasmolytic activity and are useful in treating hypertension.

Novel benzopyran derivatives, processes for their preparation and their

Benzopyran derivatives of the general formula I ##STR1## are disclosed. The compounds are therapeutic active compounds.

Pharmaceutical composition containing moxonidine (4-chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine) or its pharmaceutically acceptable salts and hydrochlorothiazide (6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide ) and, if appropriate, triamterene (2,4,7-triamino-6-phenylpteridine).

Pharmaceutical products of moxonidine and hydrochlorothiazide

Substituted indolylpropanols of the formula I ##STR1## in which R.sup.1 denotes a cyano, carboxamido, alkoxycarbonyl, hydroxyl or acetyl group,

New indolylpropanols, processes for their preparation and their use, and

Substituted 4-fluoro-isoindolines of the general formula I ##STR1## in which R denotes hydrogen or an acyl group, and their tautomeric forms and their acid addition salts have an alpha.sub.2 -antagonistic action.

Alpha-2-antagonistic substituted 4-fluoro-isoindolines

Substituted 5-phenylthio-6-aminopyrimidinones of the general formula I ##STR1## in which R denotes an amino or hydroxyl group, and their tautomeric forms and acid addition salts thereof, have diuretic, saluretic and uricosuric actions. They can be used as medicaments for the treatment of hypertension, hyperuricemia and edemas.

Substituted 5-phenylthio-6-amino-pyrimidinones, a process for their

New substituted tetrahydro-1H-pyrazolo[5,1-a]isoindoles of the formula I ##STR1## in which R.sup.1 denotes a hydrogen or halogen atom or an alkoxy group having 1 to 4 carbon atoms, R.sup.2, R.sup.3 and R.sup.4, which can be identical or different, denote a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R.sup.2 and R.sup.3 together denote the ethylene group, and X denotes a nitrogen atom or a methine group, and their acid addition salts have a long-lasting hypertensive effect and can be used as anti-hypotensives.

Antihypotensive tetrahydro-1H-pyrazolo[5,1-a]isoindoles

New isoindolin-2-yl-guanidines and isoindolin-2-yl-aminoimidazolines of the general formula ##STR1## in which R.sup.1 and R.sup.2 can be identical or different and either hydrogen or a halogen, alkyl, or alkoxy, each with 1 to 4 carbon atoms,

Hypertensive isoindolin-2-yl-aminoimidazolines and

Compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, or alkyl, R.sup.2 is halogen or alkyl, R.sup.3 is hydrogen, acyl, or saturated or unsaturated alkyl, R.sup.4 and R.sup.5 are individually hydrogen, or alkyl, wherein all alkyl and acyl groups are branched or straight-chain and each contains 1 to 4 carbon atoms, X is oxygen, nitrogen, or sulfur, Y is oxygen or nitrogen, and --X--Y-- is --O--N--, --N--O--, or --S--N--, or salts of the above, with certain exceptions. Methods of preparation of the compounds, as well as their use as anti-hypertensives are also disclosed.

Substituted oxadiazoles and thiadiazoles, and methods of preparation and

The present invention is directed to certain aminopyrimidines of the general formula ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are hydrogen, halogen, alkoxy, alkylthio, or alkyl having 1 to 4 carbon atoms, or cycloalkyl having 3 to 5 carbon atoms and R.sup.4 is hydrogen or an aliphatic or aromatic acyl group, as well as physiologically compatible acid addition salts thereof. Compounds of the present invention are useful as blood pressure lowering agents and in the treatment of glaucoma.

Substituted aminopyrimidines

A compound of the formula ##STR1## wherein R.sup.1 is chlorine, bromine, or methoxy; and R.sup.2, R.sup.3, and R.sup.4 are individually hydrogen or methyl, at least one of R.sup.2, R.sup.3, and R.sup.4 being hydrogen; or R.sup.2 and R.sup.3 together are an ethylene group and R.sup.4 is hydrogen, or a pharmaceutically acceptable acid addition salt thereof. Such compounds are useful as anti-hypertensive agents. Methods of preparation and certain novel intermediates are also disclosed.

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Hamburg, Germany

Ben Armah