Impulse Dynamics Nv

Metacure Limited

Metacure N.v.

Bella Felzen

Yuval Mika

Nissim Darvish

Shlomo Ben-Haim

Maier Fenster

Isaac Shemer

Benny Rousso

Andre G Routh

Walid Haddad

Dov Malonek

Itzik Shemer

Yaakov Haham

Richardo Aviv

According to a method and device for modulating intracellular calcium concentration in biological tissue, a stimulation probe is applied to the tissue, a non-excitatory stimulation pulse is generated, and the pulse is conveyed to the stimulation probe. In one embodiment concerning cardiac tissue, a stimulation probe is applied to a patient's heart, a signal is received from at least one sensor responsive to the patient's cardiac muscle activity, a non-excitatory stimulation pulse responsive to the signal is generated, and the pulse is conveyed to the stimulation probe.

Modulation of intracellular calcium concentration using non-excitatory electrical signals applied to the tissue

A method of promoting the healing of a lesion in a smooth muscle (), comprises selecting a smooth muscle portion having a lesion, and applying a non-excitory electric field () to the portion, which reduces the mechanical activity of the portion.

Methods for controlling labor and treating menstrual cramps in uterine muscle

An apparatus that comprises at least one electrode adapted to be placed adjacent to a portion of smooth muscle () and a controller for electrifying the electrode with a non-excitatory electric field () which does not generate excitation of the smooth muscle. The non-excitatory electric field affects the activity of the smooth muscle in a manner that controls a level of a chemical in the blood stream.

Smooth muscle controller for controlling the level of a chemical in the blood stream

Apparatus () is provided for defibrillating a heart () of a person. The apparatus () includes one or more electrodes () that are adapted to be coupled to the heart, and a control unit () that is adapted to drive the electrodes to apply electrical pulses to the heart at a rate which is typically greater than about 10 Hz. The control unit terminates the electrical pulses, so that the heart beats without fibrillation. Other embodiments are also described.

Shockless defibrillation

Method and apparatus for regulating glucose level

Method of controlling blood pressure

A method of promoting the healing of a lesion in a smooth muscle, comprising selecting a smooth muscle portion having a lesion and applying a non-excitatory electrical field to the portion, which field reduces the mechanical activity of the portion.

Smooth muscle controller

Apparatus () for performing a medical procedure on a beating heart () includes a mechanical stabilization element (), a surface () of which is adapted to be applied to a segment () of the heart to reduce motion of the segment. One or more electrodes () are fixed to the surface of the stabilization element, so as to contact the segment when the stabilization element is applied to the segment. Preferably, at least one of the one or more electrodes is adapted to apply electrical signals to the segment so as to further reduce motion thereof, while the heart continues to pump blood.

Local cardiac motion control using applied electrical signals and mechanical force

The invention comprises methods of increasing contractile force and/or the motility of a GI tract. A first method comprises selecting a portion of the GI tract and applying a non-excitatory electric field to the portion, which field increases the force of contraction at the portion. A second method comprises determining a timing of a returning wave in the GI tract and applying an electric field to at least a portion of the GI tract, which electric field reduces the response of the GI tract to the returning wave.

Method of increasing the motility of a GI tract

A method and apparatus for performing a medical procedure on a beating heart. Electrical signals are applied to the heart so as to reduce motion of a segment thereof, and the procedure is performed while the heart continues to pump blood. Preferably, the motion increases spontaneously after the signals are removed.

Local cardiac motion control using applied electrical signals

A method and apparatus for controlling activity of a heart of a living person during a medical procedure. Electrical signals are applied to the heart so as to induce a spontaneously-reversible cardioplegia thereof. The signals are preferably such that terminating application of the signals does not induce fibrillation. Most preferably, the signals have an amplitude that is below a level that would induce fibrillation upon termination thereof.

Induction of cardioplegia applied electrical signals

A method and apparatus for controlling a segment of excitable tissue, typically tissue of a heart, the segment having an intrinsic activity level. During a high phase, electrical energy of a given amplitude is applied to the segment. During a low phase, the amplitude of the electrical energy applied to the segment is reduced relative to that applied during the high phase, so that the segment's activity level increases during the low phase above the intrinsic activity level.

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Haifa, Israel

Bella Felzen