Richter Gedeon Vegyeszeti Gyar Rt

Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Bela Zsadon

Tibor Keve

Janos Galambos

Laszlo Szporny

Jozsef Szejtli

Gyorgy Fekete

Eva Fenyvesi

Egon Karpati

Arpad Kiraly

Maria Zajer Nee Balazs

Bela Kiss

Csaba Lorincz

Lilla Forgach

Gyongyver Kiraly Nee Soos

Bela Rosdy

Ferenc Tudos

Maria Szilasi

Eva Palosi

Bela Stefko

Erzsebet Lapis

Sandor Zoltan

Zsolt Szombathelyi

Katalin Csomor

Aniko Gere

Judit Laszy

Adam Sarkadi

Sandor Szabo

Lilla Forgacs

Zsolt Szentirmay

Anna Kassai Nee Zieger

Ildiko Wagner Nee Kohary

Balazs Antal

Lajos Decsei

Gyongyver Soos

Margit Barta Nee Bukovecz

Klara Horvath Nee Otta

Margit Barta N/e/ E Bukovecz

Emilia Repasi, Nee Balogh

Viktoria Bolya Nee Kassay

Mih,acu/a/ Ly Bodo

Nee Otta Horvath

The invention relates to novel 15-nitro-2.beta.,3.beta.-dihydro- and 15-nitro-2.beta.,3.beta.,6,7-tetrahydrotabersonine derivatives of the formula (I), ##STR1## wherein R.sup.1 stands for hydrogen;

15-nitro-2.beta., 3.beta.-dihydro- and

The invention relates to a new process for the preparation of 17,18-dehydro-apovincaminol-trimethoxy-benzoate of the formula (I) ##STR1## and acid addition salts thereof. According to the invention compound of the formula (I) is prepared starting from 17,18-dehydrovincamine of the formula (IIa) ##STR2## and/or 17,18-dehydro-epivincamine of formula (IIb) ##STR3## by reducing with a complex metal hydride, acylating the new hydroxy-vincaminol derivative obtained selectively with 3,4,5-trimethoxy-benzoic acid or a derivative thereof capable of acylation, optionally in the presence of a catalyst and/or an acid binding agent, and treating the corresponding acylated hydroxylderivative obtained with formic acid, in the presence of an acid chloride, and, if desired, converting the compound of formula (I) obtained into an acid addition salt thereof.

Process for the preparation of an apovincaminol derivative

The invention relates to new apovincaminol derivatives of the formula /I/ ##STR1## wherein R.sub.1 is hydrogen, nitro or halogen,

Apovincaminol derivative

The invention relates to cyclodextrin polymers swelling quickly and to a great extent in water and a process for the preparation thereof. The cyclodextrin polymers according to the invention contain as additive n-octanol having or glycol derivative or glycerol. The cyclodextrin polymers according to the invention are prepared by reacting cyclodextrin and epichlorohydrin in aqueous alkaline medium. In the reaction the cyclodextrin is reacted with 10 to 20 moles of an alkali hydroxide, 10 to 20 moles of epichlorohydrin and 2 to 8 moles of an alcohol additive, n-octanol, glycol derivative or glycerol calculated on 1 mole of cyclodextrin optionally in the presence of 10 to 15 moles of an organic solvent vaporizing at the reaction temperature or 8 to 12 moles of a high boiling organic solvent assuring heterogeneous phase.

Cyclodextrin polymers swelling quickly and to a great extent in water

The invention relates to water soluble cyclodextrin polymers substituted by ionic groups, containing structural units of formula (I) ##STR1##

Water soluble cyclodextrin polymers substituted by ionic groups and

The invention relates to the new 17,18-dehydro-apovincaminol-3',4',5'-trimethoxy-benzoate of formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of these new compounds. Still another aspect of the invention is a pharmaceutical composition for treating psoriasis.

Polycyclic compounds containing a double bond in the D-ring

The present invention relates to the compounds of the Formulae 1a and 1b and pharmaceutically acceptable acid addition salts thereof. The new 9-nitro-apovincaminol-3',4',5'-trimethoxybenzoate of the Formula 1a ##STR1## and the 11-nitro-apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 1b ##STR2## and pharmaceutically acceptable acid addition salts thereof can be prepared by nitrating the apovincaminol-3',4',5'-trimethoxy-benzoate of the Formula 11, ##STR3## if desired separating the mixture of the compounds of the Formulae 1a and 1b thus obtained into its components, if desired converting a compound of the Formula 1a or 1b thus obtained into pharmaceutically acceptable acid addition salts thereof. The new compounds of the present invention can be used in therapy in the treatment of psoriasis.

Nitro-substituted polycyclic derivatives useful in the treatment of

The invention relates to new sorbents of cellulose basis capable of forming inclusion complexes, as well as to a process for the preparation thereof. The new sorbents according to the invention are cellulose derivatives containing structural units of the general formula (I), ##STR1## wherein Cell is a group derived by removing m hydroxy groups from the glucose unit of the cellulose chain,

Sorbents of cellulose basis capable of forming inclusion complexes and a

The present invention concerns new cyclodextrin-polyvinyl alcohol polymers capable of forming inclusion complexes. The preparation of said polymers by cross-linking a cyclodextrin, a mixture of cyclodextrins, or carbohydrate mixtures containing cyclodextrins in the presence of polyvinyl alcohol, polyvinyl acetate or a polyvinyl alcohol-polyvinyl acetate copolymer, with a polyfunctional coupling reactant capable of reacting with the cyclodextrins and with the polymers present is also within the scope of the invention.

Cyclodextrin-polyvinyl alcohol polymers and a process for the

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Budapest, Hungary

Bela Zsadon