Richter Gedeon Vegyeszeti Gyar Rt

Bela Benke

Janos Kreidl

Maria Farkas Nee Kirjak

Ida Deutsch Nee Juhasz

Bela Stefko

Katalin Nogradi

Zsuzsanna Aracs Nee Tischler

Csaba Szantay

Gyorgy Kalaus

Kalman Harsanyi

Bela Hegedus

Gyorgy Domany

Eva Againe Csongor

Andras Nemes

Gyorgy Visky

Ferenc Drexler

Janos Sapi

Istvan Hegedus

Judit M Meszaros Nee Brill

Maria Stiller

Andras Rado

Hajnalka V Petho

Kalman Graf

Katalin Horvath Nee Berki

Kalmam Gaf

Judit Meszaros Nee Brill, Deceased

Lajos Szaho

The present invention relates to racemic or optically active cis octahydro-indolo [2,3-a] quinolizine diester derivatives.

Process for preparing the octahydro-indolo[2,3-a] quinolizine diester

New intermediate compounds are disclosed of the formula I, ##STR1## wherein R.sub.1 and R.sub.2 are independently alkyl having 1 to 4 carbon atoms, or acid-addition salts thereof of formula Ib, ##STR2## wherein X represents an acid residue, and a process for the preparation of the intermediate compounds.

Racemic and optically active octahydro-indolo(2,3-a) tetrahydropyranyl

The invention relates to a new crystal modification of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine H-2 receptor antagonist having the Formula (I) ##STR1## as well as to a process for preparing same. In the description, this new modification is named N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne Z (cimetidine Z).

Cimetidine Z, a new crystal modification of cimetidine

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Budapest, Hungary

Bela Benke