Roche Palo Alto LLC

Syntex (u.s.a.) Inc.

Beihan Wang

Daisy Joe Du Bois

David Bernard Smith

Eric Brian Sjogren

Denis John Kertesz

Jim W Li

Francisco Xavier Talamas

Compounds having the formula I wherein R, R, R, R, R, Y and p are as defined herein and C2-C3 is a single or double bond are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication. 

Heterocyclic antiviral compounds

The invention provides compounds of Formula (I):wherein: R&#x2013;R, A, D, and L have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.

CCR-3 receptor antagonists (I)

The invention provides compounds of Formula (I):wherein: R-R, A, L, and X have any of the values defined in the specification that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use, and methods and intermediates useful for preparing them.

Piperidine CCR-3 receptor antagonists

Piperazine CCR-3 receptor antagonists

Growing community of inventors

Santa Clara, CA, United States of America

Beihan Wang