University of Pittsburgh

The United States Government as Represented by the Department of Veterans Affairs

Beibei Chen

Rama K Mallampalli

Yuan Liu

Charleen T Chu

Toren Finkel

This document provides methods and materials for increasing the level of phosphorylated AMPK. For example, compounds (e.g., organic compounds) having the ability to increase the level of phosphorylated AMPK within cells, formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for making formulations containing compounds having the ability to increase the level of phosphorylated AMPK within cells, methods for increasing the level of phosphorylated AMPK within cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in the level of phosphorylated AMPK are provided.

Methods and materials for increasing level of phosphorylated AMPK protein

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II:

Chemical inhibition of the E3 ligase subunit FBXO7 confers neuroprotection and anti-inflammatory activity by stabilizing mitochondria

This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.

Methods and materials for increasing transcription factor eb polypeptide levels

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:

Benzathine analogs

Described herein are compounds that disrupt the interaction between Fbxo48 and phosphorylated-AMPK.

Small molecule AMPK activators

A method for treating a neurodegenerative disease or an inflammatory disorder in a subject, comprising administering to the subject in need thereof, a compound, or a pharmaceutically acceptable salt thereof, of formula II: wherein each of R-Ris independently H, halogen, optionally-substituted alkyl, amino, alkoxy or hydroxy;

A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where:

Compositions and methods for treating diseases and conditions

Novel compounds are disclosed along with methods of inhibiting the TGF&#x3b2; pathway and methods of treating Idiopathic Pulmonary Fibrosis (IPF) using such compounds.

Small molecule FIEL1 inhibitor in inflammatory and fibrotic lung injury

A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: 

A compound of Formula II, or a salt, ester, solvate, hydrate or prodrug thereof: where:Xis a branched or unbranched Calkyl, (CH)&#x2014;NH&#x2014;(CH), (CH)&#x2014;O&#x2014;(CH), or (CH)&#x2014;C(NH)&#x2014;(CH)&#x2014;NH&#x2014;(CH), where s, t and v are each, independently an integer from 1 to 5;A and B are each, independently, Caryl, Caryl-Calkyl, Cheteroaryl, or Cheteroaryl-Calkyl, each optionally substituted with 1, 2 or 3 independently selected Rgroups;C and D are each, independently, Ccycloalkyl, Ccycloalkyl-Calkyl, Cheterocycloalkyl, Cheterocycloalkyl-Calkyl, Caryl, Caryl-Calkyl, Cheteroaryl, or Cheteroaryl-Calkyl, each optionally substituted with 1, 2 or 3 independently selected Rgroups;each Ris, independently, halogen, Calkyl, Chaloalkyl, hydroxyl, Calkoxy, Chaloalkoxy, amino, Calkylamino, or di-Calkylamino; andnand pare each, independently, integers from 1 to 10.

Growing community of inventors

Wexford, PA, United States of America

Beibei Chen