Bristol-myers Squibb Compnay

Albany Molecular Research, Inc.

Bei Wang

Rulin Zhao

Bang-Chi Chen

Boguslaw Mudryk

Nicolas Cuniere

Jing Liang

Huiping Zhang

Lucius Rossano

Dau-Ming Hsieh

Adrian David

Shuang Liu

Wei Meng

Peter Tai Wah Cheng

Matthew L Isherwood

Wenge Cui

Min Hu

Paul C Lobben

Rasidul Amin

Yuh-lin Allen Yang

Mark Liu

A compound, enantiomer, prodrug, diastereomer, or salt is provided which is an activator of the enzyme glucokinase and thus is believed to be useful in as treating diabetes and related diseases, which compound has the structure (I). A method for treating diabetes and related disease employing the compound, enantiomer, prodrug, diastereomer, or salt is also provided. 

Glucokinase activators and methods of using same

Disclosed are processes for preparing tetrahydroisoquinolines, intermediates useful in the preparation of tetrahydroisoquinolines, processes for preparing such intermediates, and a crystalline form of 6-[(4S)-2-methyl-4-(naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine. Also disclosed are pharmaceutical compositions comprising tetrahydroisoquinolines, methods of using tetrahydroisoquinolines in the treatment of depression and other conditions and methods for obtaining the crystalline form. One such intermediate has the following structure: 

Tetrahydroisoquinolines and intermediates therefor

The invention is directed to processes for preparing 2-aminothiazole-5-carboxamides of formula I 

Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.

Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described.  These compounds can be useful as factor Xa inhibitors.

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Yardley, PA, United States of America

Bei Wang