Sequus Pharmaceuticals, Inc.

Miza Corporation

Bei Jin

Shi Kun Huang

Edwin Kiyoshi Oto

Mohammad Hassanipour

Samuel Zalipsky

Yolanda P Quinn

Wei-Ming Zhang

A lipid represented by the formula:wherein each of Rand Ris an alkyl or alkenyl chain having between about 8 to about 24 carbon atoms; n=0&#x2013;20; L is selected from the group consisting of (i) &#x2014;X&#x2014;(C&#x2550;O)&#x2014;Y&#x2014;, (ii) &#x2014;X&#x2014;(C&#x2550;O)&#x2014;, and (iii) &#x2014;X&#x2014;CH&#x2014;, wherein X and Y are independently selected from oxygen, NH, and a direct bond; and Z is a weakly basic moiety that has a pK of less than about 7.4 and greater than about 4.0 is described.

Neutral-cationic lipid for nucleic acid and drug delivery

A plasmid-liposome composition for transfection of a cell is described. The composition includes plasmid molecules condensed with a polycationic condensing agent and cationic liposomes. Also disclosed is a method for preparing the plasmid-liposome complexes.

Condensed plasmid-liposome complex for transfection

An improvement in a method of preparing plasmid-liposome complexes for in vivo transfection is described. The improvement includes selecting a condensing agent to condense the plasmid prior to contact with the liposomes, selecting a working medium and selecting a ratio of liposome lipid to plasmid. Also disclosed are DNA plasmid-liposome complexes formed by the method.

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Union City, CA, United States of America

Bei Jin