Nanyang Technological University

Massachusetts Institute of Technology

National University of Singapore

Bee Eng Mary Chan

Wei Yuan

Peng Chen

Hongwei Duan

Peng Li

Lain-Jong Li

Liangyu Yan

Jianwen Zhao

Yehai Yan

Paula T Hammond

Bo Liu

Qing Zhang

Nguan Soon Tan

Matthew Wook Chang

Liang Yang

Yu Du

Mouad Lamrani

Xuewei Liu

Longqing Chen

Sai Li

Zhi Dai

Wenbin Zhong

Zhangyong Si

Kaixi Zhang

Rubi Zamudio Vazquez

Jingxi He

Chuncai Zhou

Chun Kiat Yeo

Susanna Su Jan Leong

Tuan Dat Nguyen

Xiaobao Qi

Surendra Hittanahalli Mahadevegowda

Yu Qian Tina Tan

Ya Xuan Thong

Junluo Feng

Zaher Judeh

Jinye Shen

Yuguang Mu

Ashok Kumar Sundramoorthy

Kim Le Mai Hoang

Jing Wang

Bin He

Aiping Zhu

Chee Yoon Yue

The invention relates to a compound of formula Ia and/or formula Ib: or a pharmaceutically acceptable salt, solvate or prodrug thereof, where the groups are defined herein. The invention also relates to a pharmaceutical formulation comprising the compound for treating or detecting a microbial infection in a subject, a method of determining antimicrobial resistance of a microbial infection using the compound, and a method of determining an effective dose of one or more antimicrobial agents to kill a microorganism using the compound.

Biohybrid peptidoglycan oligomers

Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.

Biofunctional hydrogel for wound healing

There is provided a β-peptido sugar-copolymer having the structure of formula (I) as defined herein, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of the same. There is provided a process to make the β-peptido sugar-copolymer as defined herein. There are further provided medical applications of the β-peptido sugar-copolymer as defined herein. In a preferred embodiment, a block-like copolymer poly(amido-D-glucose)-block-poly-β-(L)-homolysine (PDGu-b-PBLK) synthesized via anionic ring-opening polymerization (ROP) demonstrates an antimicrobial efficacy, an enhanced selectivity towards different bacteria, biocompatibility vs. mammalian cells and spontaneous assembly.

Beta-peptido sugar-copolymer

Disclosed herein are polymers containing repeating units of formula (I) or copolymers containing the repeating units of formula (I) and (II), where Rto R, m, n, p, q, x and y are as defined herein. The polymers and copolymers have an antimicrobial effect and may be used therapeutically or in formulations intended for use as detergents.

Antimicrobial poly(alkylated imidazolium) salts

A hybrid nanomaterial consisting of graphene oxide (GO) nanomaterial covalently conjugated to cationic quaternized chitosan is provided. Method of preparing the hybrid nanomaterial, an antimicrobial composition containing the hybrid nanomaterial, and use of the antimicrobial composition in inhibiting growth of microorganisms in an environment are also provided.

Hybrid nanomaterial of graphene oxide nanomaterial and cationic quaternized chitosan

In various embodiments, a method for separating semiconducting single-walled carbon nanotubes from metallic single-walled carbon nanotubes may be provided. The method may include the steps of (a) passing a carbon nanotube dispersion over a charged material. The dispersion may include a mixture of the semiconducting carbon nanotubes and the metallic single-walled carbon nanotubes. The method may further include (b) passing an eluent solution through the charged material after (a). The method may also include (c) collecting an eluate including semiconducting carbon nanotubes or a mixture of semiconducting carbon nanotubes and metallic carbon nanotubes.

Methods for separating carbon nanotubes

Various embodiments relate to a method of modifying the electrical properties of carbon nanotubes. The method may include providing a substrate having carbon nanotubes deposited on a surface of the substrate, and depositing on the carbon nanotubes a coating layer comprising a mixture of nanoparticles, a matrix in which the nanoparticles are dissolved or stabilized, and an ionic liquid. A field-effect transistor including the modified carbon nanotubes is also provided.

Method of modifying electrical properties of carbon nanotubes using nanoparticles

A polyimide-carbon nanotube composite film is provided. The composite film includes a carbon nanotube, and a polyimide obtainable by imidizing a poly(amic acid).

Polyimide-carbon nanotube composite film

A method for forming a polyimide-carbon nanotube composite film on a substrate is provided. The method comprises: suspending carbon nanotubes in a solution comprising a poly(amic acid) and a suitable solvent;

Methods for forming polyimide-carbon nanotube composite film, and polyimide-carbon nanotube composite films formed thereof

The present invention is directed to a method for enriching specific species of carbon nanotubes, comprising contacting a composition of carbon nanotubes with one or more quinone compounds, reacting the carbon nanotubes with the quinone compounds, and separating the carbon nanotubes reacted with the quinone compounds from the unreacted carbon nanotubes. The present invention is also directed to a field-effect transistor comprising a semiconducting single-walled carbon nanotube enriched using a method described herein.

Quinone radicals for enriching specific species of carbon nanotubes

A method of enriching specific species of carbon nanotubes by exposing a composition of carbon nanotubes to an azo compound is provided. The method includes a) mixing the azo compound with a suspension comprising the composition of carbon nanotubes to form a mixture; b) incubating the mixture to react the azo compound with the carbon nanotubes; and c) separating a supernatant and a precipitate formed in the mixture. An electrode and a field-effect transistor comprising a single-walled carbon nanotube species enriched using the method are also provided.

Methods of enriching different species of carbon nanotubes

The invention relates to a method of modifying electrical properties of carbon nanotubes by subjecting a composition of carbon nanotubes to one or more radical initiator(s). The invention also relates to an electronic component such as field-effect transistor comprising a carbon nanotube obtained using the method of the invention. The invention also relates to the use of the modified carbon nanotubes in conductive and high-strength nanotube/polymer composites, transparent electrodes, sensors and nanoelectromechanical devices, additives for batteries, radiation sources, semiconductor devices (e.g. transistors) or interconnects.

Method for modifying electrical properties of carbon nanotubes

An object of the present invention is to provide a polymerizable composition capable of providing antimicrobial properties to ophthalmic and medical devices relatively inexpensively with ease, and an antimicrobial composition obtained by polymerizing the polymerizable composition. A polymerizable composition for ophthalmic or medical use comprising an epsilon-polylysine having (meth)acryloyl group is provided. The content of the epsilon-polylysine having (meth)acryloyl group in the polymerizable composition is preferably about 0.1 to 99% by weight, based on the whole amount of the composition. A coating agent for ophthalmic or medical use comprising the above polymerizable composition, an antimicrobial composition for ophthalmic or medical use obtained by polymerizing the above polymerizable composition, an ophthalmic or medical device comprising the antimicrobial composition, and a contact lens comprising the antimicrobial composition are also provided.

Polymerizable composition for ophthalmic and medical use and antimicrobial composition obtained by polymerizing the polymerizable composition

The present invention refers to a method of dispersing carbon nanotubes in a thermosetting resin. The method comprises: (a) contacting the carbon nanotubes with a dispersant in a solvent to form a dispersion mixture, wherein the dispersant is a graft polymer comprising a polymeric backbone and a side chain grafted to the polymeric backbone; and (b) adding the thermosetting resin to the dispersion solution to form a resin blend. The present invention also refers to a composition used for the method.

Methods for dispersing carbon nanotubes and compositions used for the methods

The present invention relates to a method for dispersing carbon nanotubes. The method may include contacting the carbon nanotubes with a solution containing chondroitin sulfate cation salt of formula (I) wherein Ris MSOand Ris H, or Ris H and Ris MSO; M is an alkaline metal, or an alkaline earth metal further bound to a monovalent counter-anion; n is at least 20.

Method for dispersing carbon nanotubes using chondroitin sulfate cation salt

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Singapore, Singapore

Bee Eng Mary Chan