Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Beatus Ofenloch-Hahnle

Hans-Peter Josel

Christoph Seidel

Helmut Lenz

Elke Faatz

Johann Karl

Urban Schmitt

Barbara Upmeier

Alfred Engel

Helmut Lill

Christa Hubner-Parajsz

Ursula-Henrike Wienhues

Andreas Dessauer

Arno Deger

Norbert Franken

Ursula Klause

Bernhard Eckert

Werner Naser

Michael Berger

Susanne Schmolke

The invention concerns a method for the determination of antigen-specific antibodies of the immunoglobulin M class in the presence of immunoglobulins of the G class and/or rheumatoid factors in body fluids by incubation with at least two different receptors R and R and optionally additional receptors wherein an essential component of R is a binding partner in a polymeric form and interference by IgG antibodies of the same antigen specificity is reduced by binding partners in a monomeric form; a reagent for determining an antigen-specific antibody of the immunoglobulin M class, as well as the use of binding partners in a monomeric form to reduce interference by IgG antibodies in the determination of antigen-specific IgM antibodies.

Antigen-specific IgM detection

The invention concerns the use of peptides which are comprised essentially of D-amino acids to eliminate interference in diagnostic methods, a method for eliminating interference in diagnostic methods by peptides which are comprised essentially of D-amino acids as well as a reagent that eliminates interference containing at least one peptide which is comprised essentially of D-amino acids.

Elimination of interference in diagnostic methods by peptides comprising

The present invention concerns an antibody against a hepatitis G virus antigen as well as a fragment of this antibody. The invention additionally concerns hybridoma cell lines as well as a conjugate that contains this antibody or the antibody fragment coupled to a biological molecule. Finally the present invention concerns the use of the antibody for the diagnostic detection of hepatitis G virus.

Antibodies against hepatitis G virus and their use for the diagnostic

Metal complexes with a charged linker

The present invention concerns a method for the determination of an analyte in a sample liquid using a metal complex capable of luminescence as an analyte-specific marker group for the production of a measuring signal in which an unspecific metal complex is additionally added as an interference elimination reagent which has a structure that is chemically related to the marker group.

Interference elimination reagent for the determination of an analyte

The present invention concerns an improved method for the determination of fibrin in body fluids in which before the actual determination the sample solution containing fibrin is incubated in the presence of thiocyanate, iodide, magnesium or/and guanidinium ions.

Method for the determination of fibrin

The present invention provides a process for the detection of analytes in body fluids containing free biotin by immunoassay with the use of biotin conjugates for the labelling, immobilization or complexing of immunological reagents, wherein the biotin present in free form is removed from the immunological reaction by incubating the sample solution with polymer particles consisting of a core and a covering which, as core, contain a polymer which has a plurality of binding sites for biotin and, as covering, at least one layer of protein, peptide, carbohydrate or co-polymer of carbohydrate and amino acids, the layer thickness of the covering being so adjusted that the coating is permeable for the free biotin but not for the biotin conjugate.

Ligand trap useful in immunoassays of biotin or free biotin containing

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Polling, Germany

Beatus Ofenloch-Hahnle