Eli Lilly and Company

Beatriz Lopez De Uralde Garmendia

Alfonso De Dios

Philip Arthur Hipskind

Ho-Shen Lin

Chuan Shih

Michael Enrico Richett

Karen Lynn Lobb

Jose Eduardo Lopez

Mary Margaret Mader

Cora Sue Grossman

James Howard Wikel

Timothy Alan Shepherd

Rosanne Bonjouklian

Chafiq Hamdouchi

Concepcion Pedregal Tercero

Robert Dean Dally

Ana Belen Bueno Melendo

Luisa Maria Martin-Cabrejas

Concepcion Sanchez-Martinez

Carlos Montero Salgado

Ivan Collado Cano

Alicia Marcos Llorente

Carlos Jaramillo Aguado

Sheila Pleite Selgas

Miriam Filadelfa Del Prado Catalina

Jose Eugenio De Diego Gomez

Tiecho Li

Michal Vieth

Maria Rosario Gonzalez Garcia

Jeremy Schulenberg York

The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis 

Benzimidazoles and benzothiazoles as inhibitors of map kinase

The present invention provides antineoplastic compounds of the formula: and antineoplastic methods.

Thiophene-and thiazolesulfonamides as antineoplastic agents

Thiophene-amd thiazolesulfonamides as antineoplastic agents

Compounds of formula (I) in which R is halo-C alkyl; halo-C alkenyl; or (CH ) Y in which n is 1 or 2 and Y is OH, CN, N , OR , SH, S(O) R , S(O) H, NH , NHR , NR R , NHCOR , NO , CO H, CONHR , 1H-tetrazol-5-yl, 5-phenyltetrazol-2-yl or PO H ; R , R , R , R , R and R are each selected independently from C alkyl, aryl and aryl-C alkyl; R is selected from C alkyl, aryl, aryl-C alkyl, and 1H-tetrazol-5-yl, carboxy-(1-4C)alkyl and 1H-tetrazol-5-yl-C alkyl; and p is 0, 1, 2 or 3; or a salt or ester thereof, provided that R is not methoxymethyl, modulate metabotropic glutamate receptor function and are useful in treating disorders of the central nervous system.

Excitatory amino acid receptor modulators

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Madrid, Spain

Beatriz Lopez De Uralde Garmendia