Johnson Matthey Inc.

Bial-portela Ca & S.a.

Beatriz Dominguez

Antonio Zanotti-Gerosa

Gabriela Alexandra Grasa

Jonathan Medlock

William Patrick Hems

Jonathan Alan Medlock

A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X, X, Y, Yor Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions. 

Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis

A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X, X, Y, Yor Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions. 

A process for performing, a coupling reaction between acetaldehyde and a terminal alkyne to yield a hydroxyalkyne is described comprising the steps of; (i) reacting without solvent, a terminal alkyne with a Lewis acidic metal salt in the presence of a alkanolamine ligand and a cyclic amine base to form a metal-alkyne complex, and (ii) adding a solution of acetaldehyde to the metal-alkyne complex.

Process for the production of a hydroxyalkyne by coupling reaction between acetaldehyde and a terminal alkyne

A substituted paracyclophane is described of formula (I) wherein Xand Xare linking groups comprising between 2 to 4 carbon atoms, Yand Yare selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z, Zand Zare substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably Xand Xare &#x2014;(CH)&#x2014; and a+b+c+d+e+f=1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions 

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Suffolk, United Kingdom

Beatriz Dominguez