Fundacio Institut Mar D'investigacions Mediques (imim)

Other

Fundacio Institut Mar D'investigacions Mediques

Bardelli, Alberto

Arena, Sabrina

Beatriz Bellosillo Paricio

Joan Albanell Mestres

Ana Rovira Guerin

Alba Dalmases Massegú

Clara Montagut Viladot

Alberto Bardelli

Sabrina Arena

Alba Dalmases Massegu

The invention relates to new identified mutations in the epidermal growth factor receptor gene, leading to amino acidic changes which highly correlate with the resistance to a therapy regimen comprising cetuximab. The invention includes peptide sequences and primers to detect the mutations, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer.

Method of treating cancer based on identifying mutations in the extracellular domain III of epidermal growth factor receptor gene

The invention relates to a new identified mutation in the epidermal growth factor receptor gene, leading to an amino acidic change which highly correlates with the resistance to a therapy regimen comprising cetuximab and the sensitivity to a therapy regimen comprising panitumumab. The invention includes peptide sequences, primers and probes to detect such a mutation, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab and/or panitumumab. In particular, the invention is useful in the therapy regimen applicable to metastasic colorectal cancer and to head and neck cancer.

Mutations in the epidermal growth factor receptor gene

Growing community of inventors

Barcelona, Spain

Beatriz Bellosillo Paricio