Gruenenthal Gmbh

Grunenthal Gmbh

Beatrix Merla

Stefan Oberboersch

Werner Guenter Englberger

Gregor Bahrenberg

Bernd Sundermann

Hagen-Heinrich Hennies

Melanie Reich

Robert Frank

Heinz Graubaum

Wolfgang Schroeder

Klaus Schiene

Babette-Yvonne Koegel

Ruth Jostock

Sven Kuehnert

Stefan Schunk

Wolfgang Schröder

Sven Kühnert

Utz-Peter Jagusch

Thomas Christoph

Corinna Sundermann

Achim Kless

Michael Engels

Edward Bijsterveld

Timo Struenker

Hans Schick

Klaus Linz

Elmar Josef Friderichs

Matthias Gerlach

Helmut Buschmann

Michael Haurand

Sabine Hees

Fritz Theil

Derek John Saunders

Helmut Sonnenschein

Tieno Germann

Claudia Hinze

Saskia Zemolka

Birgitta Henkel

Petra Bloms-Funke

Sven Frormann

Dagmar Kaulartz

Babette-Yvonne Kögel

Stefan Oberbörsch

Stephan Schunk

Heinze Graubaum

Elmark Friderichs

Nikolaus Risch

Timo Strünker

Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.

Substituted nicotinamides as KCNQ2/3 modulators

The invention relates to substituted tetrahydroisoquinolinyl-4-oxobutyric acid amides, methods for the preparation thereof, medicinal products containing these compounds and the use of these compounds for the preparation of medicinal products.

Substituted 4-(1.2,3,4-tetrahydroisoquinolin-2-yl)-4-oxobutyric acid amide as KCNQ2/3 modulators

Substituted tetrahydroimidazopyridine compounds corresponding to formula I: in which R, Rand Rhave defined meanings, processes for preparing such compounds, pharmaceutical compositions containing such compounds, and the use of such compounds for treating or inhibiting pain, epilepsy, migraine, anxiety or urinary incontinence.

Substituted tetrahydroimidazopyridine compounds and the use thereof in the treatment of pain and other conditions

Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R, R, R, R, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).

Substituted sulfonamide compounds

The invention relates to substituted N-(2-mercaptopyridin-3-yl)amides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

Substituted N-(2-mercaptopyridin-3-yl)amides as KCNQ2/3 modulators

The invention relates to substituted nicotinamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments.

Substituted sulfonamide compounds corresponding to the formula I' wherein m, n, p, X, Y, Z, R1, RA and RB have specified meanings, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these substituted sulfonamide compounds for the treatment and/or inhibition of pain or other conditions.

Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments

Sulfonylated tetrahydroazolopyrazine compounds corresponding to the formula I wherein R, R, R, R, R, R, R, R, R, R, R, A, B, W, Wand Whave the meanings defined herein, pharmaceutical compositions containing such compounds, a method for the preparation of such compounds, and the use of such compounds for treating or inhibiting various types of pain and/or other conditions mediated at least in part by the bradykinin 1 receptor (B1R).

Sulfonylated 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine compounds and their use as pharmaceuticals

Spirocyclic cyclohexane compounds corresponding to formula I a process for manufacturing such compounds, pharmaceutical compositions that contain such compounds, and the use of such spirocyclic cyclohexane compounds for the production of pharmaceuticals, and particularly for the treatment of pain.

Spirocyclic cyclohexane compounds with analgesic activity

Substituted sulfonamide compounds corresponding to formula I pharmaceutical compositions comprising them, a process for preparing them, and the use of such compounds to treat or inhibit pain and other disorders or disease states.

Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.

Substituted amide compounds

Substituted nicotinamide compounds corresponding to formula I a process for their preparation, pharmaceutical compositions containing these compounds, and the use thereof for the treatment or inhibition conditions such as pain, epilepsy, migraine, anxiety states, or urinary incontinence.

Substituted nicotinamide compounds and uses thereof

Novel cyclohexylmethyl compounds corresponding to formula I wherein R, R, R, Rand R, have the meanings given in the description. Pharmaceutical formulations containing these compounds, as well as a processes for preparing these compounds and related methods of treatment are also provided.

Substituted cyclohexylmethyl compounds

Substituted tetrahydropyrrolopyrazine compounds corresponding to the formula I: processes for their preparation, pharmaceutical compositions comprising these compounds and the use of these compounds for the treatment and/or inhibition of pain and other disorders or disease states at least partly mediated by KCNQ2/3 Kchannels.

Substituted tetrahydropyrrolopyrazine compounds and the use thereof in the treatment and/or inhibition of pain

The present invention relates to substituted benzo[d]isoxazol-3-yl-amine compounds, methods for their production, medicaments containing these compounds and the use of these compounds to produce medicaments.

Benzo[d]isoxazol-3-yl-amine compounds and their use as vanilloid receptor ligands

Growing community of inventors

Aachen, Germany

Beatrix Merla