Glaxosmithkline Biologicals Sa

Beatrice Maria Arico

Mariagrazia Pizza

Maria Scarselli

Maurizio Comanducci

Brunella Brunelli

Silvana Savino

The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.

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Poggibonsi, Italy

Beatrice Maria Arico