Merck Sharp + Dohme Corp.

Merck Sharpe & Dohme Corp.

Beatrice Le Bourdelles

Paul John Whiting

Karen Louise Hadingham

Janice Ann Myers

Peter Baxter Wingrove

The present invention relates to the cloning of novel cDNA sequences encoding the &#x3b1;and &#x3b4; receptor subunits of the human GABAreceptor; to stably co-transfected eukaryotic cell lines capable of expressing a human GABAreceptor, which receptor comprises at least one of the novel &#x3b1;and &#x3b4; receptor subunits; and to the use of such cell lines in screening for and designing medicaments which act upon the human GAGAreceptor.

Delta subunit of human GABAA receptor

The present invention provides nucleotide sequences encoding the &agr; and &dgr; subunits of the human GABA receptor, preparations of &agr; and &dgr; receptor subunit proteins, preparations of receptors including &agr; or &dgr; polypeptides, expression vectors including the nucleotide sequences, stably co-transfected eukaryotic cells and methods of their preparation and methods of screening for and designing medicaments which act upon the GABA receptor.

Human &agr;4 receptor subunit of the GABA-A receptor

Human NMDA R2A receptor subunit and isoforms of the human NMDA-R1

The present invention relates to a stably co-transfected eukaryotic cell line capable of expressing a GABA-A receptor, particularly a human GABA-A receptor, which receptor comprises at least one alpha, one beta and one gamma subunit; to the cloning of novel cDNA sequences encoding the .alpha.-2, .alpha.-3, .alpha.-5, .alpha.-6 and .beta.-2 subunits of the human GABA-A receptor; and to the use of the cell line in designing and developing GABA-A receptor subtype-selective medicaments.

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Sawbridgeworth, United Kingdom

Beatrice Le Bourdelles