Avidity Biosciences, Inc.

Beatrice Diana Darimont

Rob Burke

Venkata Ramana Doppalapudi

Michael Caramian Cochran

Barbora Malecova

Andrew John Geall

David Sai-Ho Chu

Gulin Erdogan Marelius

Michael David Hood

Yunyu Shi

Rachel Elizabeth Johns

David Sala Cano

Palani Balu

Tyler Albin

Usue Etxaniz Irigoien

Isaac Marks

Rachel Johns

Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle dystrophy (DM1).

Compositions and methods of treating muscle dystrophy

Disclosed herein are antibody oligonucleotide conjugates and pharmaceutical compositions that induce an alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping. Also described herein include methods for treating muscle dystrophy including Duchenne muscular dystrophy that comprises administering antibody oligonucleotide conjugates or a pharmaceutical composition that induces alteration in an incorrectly spliced dystrophin mRNA transcript to induce exon 44 skipping.

Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping

Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

Nucleic acid-polypeptide compositions and uses thereof

Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating muscle atrophy or myotonic dystrophy.

Compositions and methods of treating muscle atrophy and myotonic dystrophy

Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating facioscapulohumeral muscular dystrophy (FSHD).

Compositions and methods of treating facioscapulohumeral muscular dystrophy

Disclosed herein are polynucleic acid molecules, pharmaceutical compositions, and methods for treating Facioscapulohumeral muscular dystrophy.

Compositions and methods of treating Facioscapulohumeral muscular dystrophy

Disclosed herein, in certain embodiments, are anti-transferrin receptor antibodies, anti-transferrin receptor antibody conjugates, and pharmaceutical compositions which comprise the anti-transferrin receptor antibodies or conjugates. In some embodiments, also disclosed herein are methods of delivering a payload utilizing an anti-transferrin receptor antibody described herein, and methods of treatment with use of an anti-transferrin receptor antibody described herein.

Growing community of inventors

San Diego, CA, United States of America

Beatrice Diana Darimont