Prolume, Ltd.

Unitargeting Research As

Beate Stern

Ian Pryme

Hanne Ravneberg

Albert Tauler

John Hesketh

Christine Gjerdrum

John Edward Hesketh

Ian Fraser Pryme

John E Hesketh

The present invention relates to a method of producing a target protein, which method comprises expressing said protein in a host cell which contains a nucleic acid molecule which encodes a chimeric protein, said chimeric protein comprising a signal peptide from a non-mammalian bulk-secreted protein and said target protein; nucleic acids, vectors, host cells and kits for carrying out the method are also described.

Protein expression system

The invention relates to a kit to be used for the identification of a secretion cassette, which in eukaryotic cells gives rise to a higher level of synthesis/secretion of a protein of interest, the coding sequence of which being flanked by the first and the second set of genetic elements, respectively, compared to the other secretion cassettes present in the kit containing the coding sequence at the corresponding position, as well as to a method wherein the kit is used and the use of the kit, whereby the best secretion cassette will be obtained.

Kit for the optimisation of protein synthesis/secretion

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Bergen, Norway

Beate Stern